In an earlier video, I presented data for apigenin’s ability to increase levels of NAD+. In addition to apigenin’s impact on NAD+, apigenin supplementation increases muscle mass, strength, and treadmill running distance in both young and old mice.
Video link for NAD+ is increased in response to apigenin: https://youtu.be/5-2YoGctcCk?list=UUT…
Paper links:
Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7: https://pubmed.ncbi.nlm.nih.gov/29108…
Apigenin Ameliorates the Obesity‐Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice: https://onlinelibrary.wiley.com/doi/a…
Antioxidant Apigenin Relieves Age-Related Muscle Atrophy by Inhibiting Oxidative Stress and Hyperactive Mitophagy and Apoptosis in Skeletal Muscle of Mice: https://pubmed.ncbi.nlm.nih.gov/32857…
Do you think that other natural product activators of nrf2 might exhibit similar effects?
I haven’t done a proper lit review for nrf2, so at the moment, I’m not sure.