Methionine Restriction Extends Lifespan-What’s Optimal For Protein Intake? n=1 Analysis

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Papers referenced in the video:

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

Low methionine ingestion by rats extends life span

Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study

Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study

Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age

Association between low-density lipoprotein cholesterol and cardiovascular mortality in statin non-users: a prospective cohort study in 14.9 million Korean adults

Blood counts in adult and elderly individuals: defining the norms over eight decades of life


2 thoughts on “Methionine Restriction Extends Lifespan-What’s Optimal For Protein Intake? n=1 Analysis

  1. Tyler

    I love the detailed analysis, this is great work!!! It does bring up an interesting question about the amount of weight you give each variable. It seems to me that giving more weight to the variables that are most influential in the overall score might be the best way to prioritize your protocol. For example making the center bullseye of your target RDW and/or glucose, then the first ring, CRP and WBC (count) and albumin, moving out to the outermost rings of the target like: Creatinine/alkaline Phosphatase: What do you think?


    1. Michael Lustgarten Post author

      Thanks Tyler. I can see how adding weights to biomarkers can be valuable, but I’m wary. FOr example, albumin is the most concentrated protein in blood-should that be weighted more than RDW? I’m not only trying to optimize biological age, but all of the big picture biomarkers, too. For for now, they each have equal weight…



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