Calorie Restriction And Fasting Extend Lifespan

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4 thoughts on “Calorie Restriction And Fasting Extend Lifespan”

  1. Ole Bisgaard Pedersen's avatarOle Bisgaard Pedersen

    I wonder what the sweetspot is for ferritin given the fact that low ferritin can cause higher RDW, while on the other hand high ferritin can cause increased “corrosion” due to oxidative stress?

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      1. Ole Bisgaard Pedersen's avatarOle Bisgaard Pedersen

        Hi Michael,

        According to this study a ferritin level within (40–120 μg/L), can cause higher RDW. A weakness of the study is that was done on diabetics.

        https://www.nature.com/articles/s41598-023-47678-5

        I like to keep my ferritin not much higher than 50, but I have no idea about my RDW value, yet

        My assumption is that there is a lot variation between individuals. Some may thrive in the low range, while others suffer fatigue and less stamina.

        PS. It would be nice if researchers would start to include non- diabetics 🙂

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      2. Michael Lustgarten's avatarMichael Lustgarten Post author

        Hi Ole, thanks for that, as I hadn’t seen this paper!

        Ferritin follows an inverse U-shape during aging (low in youth and advanced age, peak from 30 – 69y)-see Fig 1 in this paper: https://pubmed.ncbi.nlm.nih.gov/10874269/

        The study that you posted included people > 65y, and it’s probable that their ferritin levels were declining relative to the mid-life peak, and hence were inversely correlated with RDW, which increases during aging.

        When considering that low ferritin is also found in youth, I’d recommend additional biomarker testing for more insight, especially those specific to the liver. For ex., if albumin is low, too, it suggests that low ferritin is not youthful, but aged (ferritin and albumin are produced by the liver). But, if albumin is high, then low ferritin could be a signal for youth, not advanced age.

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