Have a look at my latest book update, including ~50 references that link microbial burden with all of the Hallmarks of Aging! https://www.amazon.com/dp/B01G48A88A

Papers referenced int the video: Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation: https://pubmed.ncbi.nlm.nih.gov/21795…​ Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: […]

Papers referenced in the video: Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130883/ CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism: https://pubmed.ncbi.nlm.nih.gov/27304511/ Aerobic and resistance exercise training reverses age-dependent decline in NAD + salvage capacity in human skeletal muscle: https://pubmed.ncbi.nlm.nih.gov/31207144/

Papers referenced in the video: The Hallmarks of Aging: https://www.ncbi.nlm.nih.gov/pmc/arti…​ Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives: https://www.ncbi.nlm.nih.gov/pmc/arti…​ Telomeres and the natural lifespan limit in humans: https://www.ncbi.nlm.nih.gov/pmc/arti…​ Telomere Length and All-Cause Mortality: A Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/30254…​ Comparability of biological aging measures in the National […]

In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis. In addition, I’ve tested my HDL […]

Papers referenced in the video: DNA methylation GrimAge strongly predicts lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/30669…​ GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality: https://pubmed.ncbi.nlm.nih.gov/33211…​ Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic […]

The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes. Viruses, including SARS-CoV-2 and HSV-1 cause mitochondrial dysfunction-more specifically, they cause mitochondria to release some of their DNA, which triggers antiviral immunity. When considering that blood levels of mitochondrial DNA increase during aging, […]

In an earlier video, I presented data for apigenin’s ability to increase levels of NAD+. In addition to apigenin’s impact on NAD+, apigenin supplementation increases muscle mass, strength, and treadmill running distance in both young and old mice. Video link for NAD+ is increased in response to apigenin: https://youtu.be/5-2YoGctcCk?list=UUT… Paper […]

The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.

Here’s an interview that I did with Richard at Modern Healthspan, one of the best interviewers in aging! Part I: Monitoring Biomarkers to Reverse Aging: Part II, Diet, CR & Fasting: Part III: Exercise, Protein Part IV: Optimize Nutrients Through Diet Part V: Inhibit CD38 to Optimize NAD Part VI: […]

A reduced mortality risk and an increased lifespan has been reported for people who have APOE2 alleles, when compared with APOE3 or APOE4, but beyond associations, data for lifespan in APOE-expressing mice was recently reported, evidence that supports a causative role for APOE on longevity.

In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and […]

LPS increases during aging, which may explain the age-related increase for CD38 and decreased NAD+. LPS is decreased on a calorie restricted diet, but what else can reduce it? In this video, I present evidence for intestinal alkaline phosphatase’s (IAP) role on LPS, and posit that interventions that increase IAP […]

Blood urea nitrogen (BUN) is one of the 19 variables found on the biological age calculator, aging.ai. It measures the amount of nitrogen, as contained in urea (i.e., blood urea nitrogen, BUN) in your blood. The reference range for BUN is 5 – 20 mg/dL, but within that range, what’s […]

Consistent exercise training would seem like the obvious choice to reduce resting heart rate (RHR) and to increase heart rate variability (HRV). Are there other factors that can impact these variables? Body weight and daily calorie intake may affect RHR and HRV, and in the video I present 700+ days […]

Many interventions have been reported to increase NAD levels, but dietary components that can impact NAD levels are less discussed. Here, I highlight the ability of two dietary components, apigenin and quercetin to increase NAD, and report the foods that contain these metabolites.