Author Archives: Michael Lustgarten

About Michael Lustgarten

Scientist II, Tufts University Human Nutrition Research Center on Aging (2016-present) Ph.D, Physiology, University of Texas Health Science Center at San Antonio, 2009 B.S., Biochemistry, Queens College, 2003 B.A, English Textual Studies, 1994, Syracuse University

How Many Calories Are Optimal For Health?

Spermidine Impacts Health and Longevity

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Papers referenced in the video:

Polyamine-rich food decreases age-associated pathology and mortality in aged mice https://pubmed.ncbi.nlm.nih.gov/19735716/

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats https://pubmed.ncbi.nlm.nih.gov/32285289/

Cardioprotection and lifespan extension by the natural polyamine spermidine https://pubmed.ncbi.nlm.nih.gov/27841876/

Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy https://pubmed.ncbi.nlm.nih.gov/28386016/

Higher spermidine intake is linked to lower mortality: a prospective population-based study https://pubmed.ncbi.nlm.nih.gov/29955838/

Polyamines in aging and disease https://pubmed.ncbi.nlm.nih.gov/21869457/

Dietary spermidine improves cognitive function https://pubmed.ncbi.nlm.nih.gov/33852843/

The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial https://pubmed.ncbi.nlm.nih.gov/33211152/

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial https://pubmed.ncbi.nlm.nih.gov/30388439/

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline https://pubmed.ncbi.nlm.nih.gov/29315079/

A review of dietary polyamines: Formation, implications forgrowth and health and occurrence in foods https://www.sciencedirect.com/science/article/abs/pii/S0308814604002961

In vitro digestion of spermidine and amino acids in fresh and processed Agaricus bisporus mushroom https://pubmed.ncbi.nlm.nih.gov/33233206/

Decrease in polyamines with aging and their ingestion from food and drink https://pubmed.ncbi.nlm.nih.gov/16428322/

How Many Steps Per Day Is Associated With Reduced Risk Of Death For All Causes?

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Paper referenced in the video:

How many steps a day to reduce the risk of all-cause mortality? A dose–response meta-analysis https://pubmed.ncbi.nlm.nih.gov/34808011/

Physical Activity, Body Weight, And Diet Affect Resting Heart Rate And Heart Rate Variability

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Papers referenced in the video:

Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults

https://pubmed.ncbi.nlm.nih.gov/32023264/

Heart rate variability with photoplethysmography in 8 million individuals: a cross-sectional study

https://pubmed.ncbi.nlm.nih.gov/33328029/

Metformin Impairs Exercise Training-Related Improvements In Older Adults

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Papers referenced in the video:

Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a https://pubmed.ncbi.nlm.nih.gov/34725961/

Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial https://pubmed.ncbi.nlm.nih.gov/31557380/

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://pubmed.ncbi.nlm.nih.gov/30548390/

Quantifying Biological Age: Blood Test #5 in 2021

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Links to biological age calculators:

Levine’s PhenoAge calculator is embedded as an Excel file: https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

aging.ai

Papes referenced in the video:

Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies https://www.bmj.com/content/348/bmj.g1903

Fisetin is a senotherapeutic that extends health and lifespan https://pubmed.ncbi.nlm.nih.gov/30279143/

Fruit And Vegetable Intake: How Many Servings/Day Is Optimal?

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Paper referenced in the video:

Fruit and Vegetable Intake and Mortality Results From 2 Prospective Cohort Studies of US Men and Women and a Meta-Analysis of 26 Cohort Studies

https://pubmed.ncbi.nlm.nih.gov/33641343/

Fasting Drives The Geroprotective Effects Of A Calorie-Restricted Diet

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Paper referenced in the video:

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice https://www.nature.com/articles/s42255-021-00466-9

Chocolate Intake Is Associated With Reduced All-Cause And Cause-Specific Mortality Risk

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Papers referenced in the video: Chocolate consumption and all-cause and cause-specific mortality in a US population: a post hoc analysis of the PLCO cancer screening trial https://pubmed.ncbi.nlm.nih.gov/34329196/

Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons https://pubmed.ncbi.nlm.nih.gov/15755830/

Other RCTs for the effect of chocolate on health: Sub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized Trial https://pubmed.ncbi.nlm.nih.gov/31744119/

Habitual cocoa intake reduces arterial stiffness in postmenopausal women regardless of intake frequency: a randomized parallel-group study https://pubmed.ncbi.nlm.nih.gov/27881914/

High Flavonoid Cocoa Supplement Ameliorates Plasma Oxidative Stress and Inflammation Levels While Improving Mobility and Quality of Life in Older Subjects: A DoubleBlind Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/31056655/

Dietary epicatechin improves survival and delays skeletal muscle degeneration in aged mice https://pubmed.ncbi.nlm.nih.gov/30096038/

USDA flavonoid database https://www.ars.usda.gov/arsuserfiles/80400525/data/flav/flav_r03-1.pdf