Germ-free mice (animals don’t have a microbiome) live longer than microbiome-containing mice, but it’s impractical for people to live in a bubble for their entire lifespan. As a more practical approach, which microbiome-derived factors impact lifespan, and can they be modified? Dietary supplementation with acarbose increases lifespan, and one reason […]
How does the gut microbiome and its metabolic products affect muscle mass, muscle composition, and physical function? In this presentation, I review the evidence, then I present recent data from our group.
Here’s my latest academic publication! https://link.springer.com/article/10.1007/s12603-020-1344-1
Here’s my book, available now! https://www.amazon.com/dp/B01G48A88A
I recently heard centenarian Bernando Lapallo say that he boils his drinking water (http://www.abc15.com/news/local-news/water-cooler/valley-man-celebrates-114th-birthday-shares-his-longevity-secrets). Whether this is a contributor to or is merely associated with his longevity is debatable. What will boiling your water do, prior to drinking it, and is it worth the effort? The ability of our immune […]
Our story begins with Michael Rose, who used an experimental evolution approach to breed flies that live more than 2-fold longer than controls (Rose 1999). In contrast with the one gene at a time knockout or overexpression strategy that is ubiquitous in modern biology, Rose separated initially genetically homogeneous flies into […]