Category Archives: Kidney function

Kidney Function: What’s Optimal For Health (And Potentially, Longevity)?

Leave a reply

Join us on Patreon!
https://www.patreon.com/MichaelLustgartenPhD

TruDiagnostic Discount Link (Epigenetic Testing)
CONQUERAGING!
https://bit.ly/3Rken0n

Bristle Discount Link (Oral Microbiome Quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Quantify Discount Link (At-Home Blood Testing)
https://getquantify.io/mlustgarten

Cronometer Discount Link (Daily Diet Tracking):
https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

If you’d like to support the channel, you can do that with the website,
Buy Me A Coffee!
https://www.buymeacoffee.com/mlhnrca

Papers referenced in the video:
A Physiology Clock for Human Aging (preprint)
https://www.biorxiv.org/content/10.1101/2022.04.14.488358v1.full

Age-related changes in clinical parameters and their associations with common complex diseases
https://pubmed.ncbi.nlm.nih.gov/26623014/

Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis
https://pubmed.ncbi.nlm.nih.gov/23360717/

Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716867/

Advertisement

AGE Products Impact Lifespan: Impact Of Hyperglycemia, Kidney Function, And The Microbiome

Leave a reply

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Papers referenced in the video:

Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan https://pubmed.ncbi.nlm.nih.gov/18599606/

Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression https://pubmed.ncbi.nlm.nih.gov/17525257/

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N 6-carboxymethyllysine https://pubmed.ncbi.nlm.nih.gov/35241804/

Plasma Carboxymethyl-Lysine, an Advanced Glycation End Product, and All-Cause and Cardiovascular Disease Mortality in Older Community-Dwelling Adults https://pubmed.ncbi.nlm.nih.gov/19682127/

Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community dwelling women https://pubmed.ncbi.nlm.nih.gov/19448391/

Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor KappaB in PBMCs https://pubmed.ncbi.nlm.nih.gov/12606501/

Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans https://pubmed.ncbi.nlm.nih.gov/30823632/

Novel associations between blood metabolites and kidney function among Bogalusa Heart Study and Multi-Ethnic Study of Atherosclerosis participants https://pubmed.ncbi.nlm.nih.gov/31720858/

Serum Carboxymethyl-lysine, a Dominant Advanced Glycation End Product, is Associated with Chronic Kidney Disease: the Baltimore Longitudinal Study of Aging https://pubmed.ncbi.nlm.nih.gov/19853477/

Centenarian Blood Test Analysis (n=1,754)

Leave a reply

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Papers referenced in the video:

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians https://pubmed.ncbi.nlm.nih.gov/31908434/

Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study https://pubmed.ncbi.nlm.nih.gov/28811570/

Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age https://pubmed.ncbi.nlm.nih.gov/29113935/

Age and sex variation in serum albumin concentration: an observational study https://pubmed.ncbi.nlm.nih.gov/26071488/

Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies https://pubmed.ncbi.nlm.nih.gov/33152050/

The gamma gap predicts 4-year all-cause mortality among nonagenarians and centenarians https://pubmed.ncbi.nlm.nih.gov/29348636/

Triglyceride centenarian studies are referenced in this post from my website: https://michaellustgarten.com/2020/02/19/blood-testing-whats-an-optimal-value-for-triglycerides-2/

Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies https://pubmed.ncbi.nlm.nih.gov/24164719/

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults https://pubmed.ncbi.nlm.nih.gov/33313654/

Kidney Function Declines During Aging-Can It Be Reversed?

2 Replies

Discussed in the video:

Data for changes in kidney function during aging, kidney function values that are associated with an increased risk of death for all causes

What’s my data for kidney function, 2006 – 2020?

Can diet impact kidney function?

Within my data, which foods are correlated with good kidney function?

How are the individual components of these foods (fiber, protein, omega-3 fatty acids) correlated with kidney function?

Quantifying Biological Age: Blood Test #5 in 2020

10 Replies

My latest blood test results are in-how’s my biological age?

In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them with diet going forward.

Biological Age: Optimal On A Carnivore Diet?

Leave a reply

After going on Joe Rogan’s podcast, Paul Saladino, MD, posted his show notes, which included his blood test results. Based on that data, is his biological age optimal while on a carnivore diet?

Blood Test Analysis: 100 – 111y (Centenarians, Semi- and Super-Centenarians)

3 Replies

In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and super-centenarians (110y+).

 

Biological Age Test #4 in 2020: Getting Better or Getting Worse?

15 Replies

My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them going forward.

Quantifying Biological Age: Blood Test Measurement #3 in 2020

Leave a reply
In this video, I discuss data for 6 blood test measurements since 2018 that show a Phenotypic (Biological) Age that is ~14 years than my current age (47y).
 
https://youtu.be/85t8vmIgR6s

Blood Test Analysis In A 100 Year Old Subject

Leave a reply

What are the blood biomarkers of a centenarian, and is there room for improvement? Find out in the video below!

https://www.youtube.com/watch?v=XhCUuxhxmpg