Category Archives: Kidney function

AGE Products Impact Lifespan: Impact Of Hyperglycemia, Kidney Function, And The Microbiome

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Papers referenced in the video:

Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan https://pubmed.ncbi.nlm.nih.gov/18599606/

Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression https://pubmed.ncbi.nlm.nih.gov/17525257/

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N 6-carboxymethyllysine https://pubmed.ncbi.nlm.nih.gov/35241804/

Plasma Carboxymethyl-Lysine, an Advanced Glycation End Product, and All-Cause and Cardiovascular Disease Mortality in Older Community-Dwelling Adults https://pubmed.ncbi.nlm.nih.gov/19682127/

Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community dwelling women https://pubmed.ncbi.nlm.nih.gov/19448391/

Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor KappaB in PBMCs https://pubmed.ncbi.nlm.nih.gov/12606501/

Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans https://pubmed.ncbi.nlm.nih.gov/30823632/

Novel associations between blood metabolites and kidney function among Bogalusa Heart Study and Multi-Ethnic Study of Atherosclerosis participants https://pubmed.ncbi.nlm.nih.gov/31720858/

Serum Carboxymethyl-lysine, a Dominant Advanced Glycation End Product, is Associated with Chronic Kidney Disease: the Baltimore Longitudinal Study of Aging https://pubmed.ncbi.nlm.nih.gov/19853477/

Centenarian Blood Test Analysis (n=1,754)

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Papers referenced in the video:

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians https://pubmed.ncbi.nlm.nih.gov/31908434/

Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study https://pubmed.ncbi.nlm.nih.gov/28811570/

Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age https://pubmed.ncbi.nlm.nih.gov/29113935/

Age and sex variation in serum albumin concentration: an observational study https://pubmed.ncbi.nlm.nih.gov/26071488/

Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies https://pubmed.ncbi.nlm.nih.gov/33152050/

The gamma gap predicts 4-year all-cause mortality among nonagenarians and centenarians https://pubmed.ncbi.nlm.nih.gov/29348636/

Triglyceride centenarian studies are referenced in this post from my website: https://michaellustgarten.com/2020/02/19/blood-testing-whats-an-optimal-value-for-triglycerides-2/

Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies https://pubmed.ncbi.nlm.nih.gov/24164719/

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults https://pubmed.ncbi.nlm.nih.gov/33313654/

Kidney Function Declines During Aging-Can It Be Reversed?

Discussed in the video:

Data for changes in kidney function during aging, kidney function values that are associated with an increased risk of death for all causes

What’s my data for kidney function, 2006 – 2020?

Can diet impact kidney function?

Within my data, which foods are correlated with good kidney function?

How are the individual components of these foods (fiber, protein, omega-3 fatty acids) correlated with kidney function?

Quantifying Biological Age: Blood Test #5 in 2020

My latest blood test results are in-how’s my biological age?

In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them with diet going forward.

Biological Age: Optimal On A Carnivore Diet?

After going on Joe Rogan’s podcast, Paul Saladino, MD, posted his show notes, which included his blood test results. Based on that data, is his biological age optimal while on a carnivore diet?

Blood Test Analysis: 100 – 111y (Centenarians, Semi- and Super-Centenarians)

In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and super-centenarians (110y+).

 

Biological Age Test #4 in 2020: Getting Better or Getting Worse?

My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them going forward.

Quantifying Biological Age: Blood Test Measurement #3 in 2020

In this video, I discuss data for 6 blood test measurements since 2018 that show a Phenotypic (Biological) Age that is ~14 years than my current age (47y).
 

Blood Test Analysis In A 100 Year Old Subject

What are the blood biomarkers of a centenarian, and is there room for improvement? Find out in the video below!

Serum Creatinine: What’s Optimal?

In this relatively short clip, I talk about how serum levels of creatinine change during aging, what levels are associated with risk of death for all causes, and I show my own data for 15+ years!