Join me on Patreon! https://www.patreon.com/MichaelLustga…
Biological Age
Paper references for Levine’s Phenotypic Age calculator and aging.ai: An epigenetic biomarker of aging for lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/29676… Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations: https://pubmed.ncbi.nlm.nih.gov/29340…
Results for my first blood test in 2021 are in-what’s my biological age, and how am I optimizing it? If you’re interested in calculating your biological age, the spreadsheet is included as an Excel file in this link:
Discussed in the video: What’s my biological age on blood test #6 in 2020? What’s my average biological age for 2020, and how does it compare with 2019? Are there links between calorie intake, cardiovascular fitness (RHR, HRV), and diet composition with my biological age?
Here’s an interview that I did with Richard at Modern Healthspan, one of the best interviewers in aging! Part I: Monitoring Biomarkers to Reverse Aging: Part II, Diet, CR & Fasting: Part III: Exercise, Protein Part IV: Optimize Nutrients Through Diet Part V: Inhibit CD38 to Optimize NAD Part VI: […]
My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them with diet going forward.
After going on Joe Rogan’s podcast, Paul Saladino, MD, posted his show notes, which included his blood test results. Based on that data, is his biological age optimal while on a carnivore diet?
My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them going forward.
Blood urea nitrogen (BUN) is one of the 19 variables found on the biological age calculator, aging.ai. It measures the amount of nitrogen, as contained in urea (i.e., blood urea nitrogen, BUN) in your blood. The reference range for BUN is 5 – 20 mg/dL, but within that range, what’s […]
In this video, I discuss data for 6 blood test measurements since 2018 that show a Phenotypic (Biological) Age that is ~14 years than my current age (47y). https://youtu.be/85t8vmIgR6s
Here’s a video clip about my latest Biological Age measurement!
Most often overlooked on a standard blood test are the mean corpuscular volume (MCW) and Red Blood Cell Distribution Width (RDW). How do they change during aging, and what’s associated with all-cause mortality risk? Also, with the goal of optimizing MCV and RDW, how does my diet correlate with these […]
Interestingly, we recorded this as I was recovering from a respiratory infection. Was it SARS-CoV-2, or influenza? I’ll know later this week! https://www.bisu.bio/biohacking-to-100-longevity-lessons-from-15-years-of-self-tracking-ft-michael-lustgarten-phd/
In the first 45 minutes, discuss each of the biomarkers contained within Levine’s Biological Age calculator, Phenotypic Age. After that, I answer questions from the audience and we discuss all things related to aging. https://www.youtube.com/watch?v=8hs2n7U7J-k&t=30s
Here’s a recent podcast that was recorded with Julian Hayes II at Optimal Health for Busy Entrepreneurs: https://theartoffitnessandlife.com/episode20/ Enjoy!
Exactly 1 month ago, my first biological age measurement of 2020 was 32.75y (https://michaellustgarten.com/2020/02/14/biological-age-32-75y-chronological-age-47y-first-2020-measurement/). When considering that my chronological age is 47y, that’s a 14 year improvement, but I wasn’t (and still aren’t) satisfied. When I sent my blood for analysis, I was battling a mild upper respiratory infection (cough, […]
Measurement of biological age with Levine’s Phenotypic Age calculator is strongly correlated with chronological age (r=0.94; see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). In 2019, I measured all 9 of its analytes 3 times, with biological age readings of 35.39y, 35.58y, and 31.3y, for an average 2019 biological age of 34.09y (see https://michaellustgarten.com/2019/11/01/biological-age-31-3y-chronological-age-46y/). That’s 12 […]
Here’s a link to a recent interview, https://biohackstack.com/posts/michael-lustgarten/?fbclid=IwAR059Jf6eT4SyvsqTxHaSir2hQuXKjV5R6kLg-7Df1Kc4c7ZKM6Tw-0qRwY Including: How (and why) did you get involved in research in aging and the human microbiome? How did you get started in health optimization / quantified-self? What are your thoughts on biological age testing? Which tests (epigenetic, blood biomarkers, telomere, etc) and […]
The reference range for uric acid is 4.0 – 8 mg/dL for men, and 2.5 – 7 mg/dL for women. Are these values optimal for health? To answer that question, let’s have a look at how circulating levels of uric acid change during aging, and their association with risk of […]
Besides diet (https://michaellustgarten.com/2019/12/07/slowing-epigenetic-aging-with-diet/), are there other factors that may impact epigenetic aging? First, let’s have a look at clinically relevant variables, including inflammation, the lipid profile, kidney function, blood pressure, and body size/dimensions (Liu et al. 2019): One of the strongest correlations for the clinical variables with epigenetic aging (AgeAccelGrim) […]
Having a faster rate of epigenetic aging, as measured by the epigenetic age metric, AgeAccelGrim, is associated with a significantly increased risk of death for all causes in a variety of cohorts, including the Framingham Heart Study (FHS), the Women’s Health Initiative (WHI) study, the InChianti study, the Jackson Heart […]
Three studies have investigated the ability of blood test analytes to predict biological age. First, when considering the top 20 variables that were associated with biological age in aging.ai, albumin contributed most to this prediction, almost 2x more than circulating levels of glucose (Mamoshina et al. 2018): Second, albumin was […]
To make it easier to review the aging and all-cause mortality data for the circulating biomarkers that are contained within the biological age calculator, Phenotypic Age (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/), here’s a checklist! 1. Albumin: https://michaellustgarten.com/2019/09/22/optimizing-serum-levels-of-albumin-data-from-20-blood-tests/ 2. Creatinine: https://michaellustgarten.com/2019/11/18/optimizing-biologic-age-creatinine/ 3. Glucose: https://michaellustgarten.com/2019/10/04/blood-glucose-whats-optimal/ 4. C-reactive protein: https://michaellustgarten.com/2019/10/19/optimizing-biological-age-crp/ 5. Lymphocyte %: https://michaellustgarten.com/2019/11/16/lympho-mortal/ 6. Mean […]
Creatinine is one of the 9 blood test variables included on the biological age calculator, Phenotypic Age (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). The reference range for women and men is 0.5 – 1.1, and 0.6 – 1.2 mg/dL respectively, but within that range, what’s optimal for health and longevity? To answer that question, it’s […]
The percentage of lymphocytes is one of the 9 blood test variables included in the biological age calculator, Phenotypic Age (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). The reference range for lymphocyte % is 20 – 40% of the total amount of white blood cells (WBCs), but are higher or lower values optimal for health and […]
My average biological age in 2019 is 12 years younger than my chronological age (46y) based on the Phenotypic Age calculator (https://michaellustgarten.com/2019/11/01/biological-age-31-3y-chronological-age-46y/), and 16y younger based on aging.ai (https://michaellustgarten.com/2019/11/04/years-of-biological-aging-in-the-past-4-years/). One factor that likely contributes to my relatively youthful biological age is my diet. Shown below is my average daily dietary […]
In an earlier post (https://michaellustgarten.com/2018/06/26/maximizing-health-and-lifespan-is-calorie-restriction-essential/), I documented my aging.ai biologic age for 13 blood test measurements from 2016 – 2019. If you missed that post, here are those data: Note that note my average biologic age has slowly increased from 2016 to 2019, from 28y in 2016 (2 measurements), to […]
On June 10, 2019 (for the first time) I measured all of the blood test variables that are included in the biologic age calculator, Phenotypic Age, and ended up with a biological age = 35.39y (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). While that value is 23% younger than my chronological age (46y), I knew that […]
High sensitivity C-Reactive Protein (CRP) is one of the 10 variables included in the biological age calculator, PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). The reference range for CRP is 0 – 3 mg/L, but within that range, what’s optimal? To answer that question, it’s important to know how CRP changes during aging, and what […]
Mean corpuscular volume (MCV) is one of the 10 variables included in the biological age calculator, PhenoAge (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). It’s calculated by dividing the fraction of the blood that contains RBCs (hematocrit) by RBCs (MCV = hematocrit/RBC), thereby identifying the average volume contained within red blood cells. Although the MCV reference […]
Circulating levels of white blood cells (WBCs) are one of the 10 variables used to quantify biological age with PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age). The reference range for WBCs is 4.5 – 11 *10^9 cells/L, but within that range, what’s optimal? Several studies have reported that WBCs greater than 5 are associated with […]
Alkaline phosphatase (ALP) is one of the 10 variables used to quantify biological age with PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age). The reference range for alkaline phosphatase is 20 – 140 IU/L*, but within that range, what’s optimal? Two separate meta-analyses have investigated the association between serum levels of ALP with risk of death […]
The reference range for circulating levels of glucose is 70-130 mg/dL. That’s a wide range, so what’s optimal, especially considering that glucose is one of the variables used to quantify of biological age (https://michaellustgarten.com/2019/09/09/quantifying-biological-age)? In the largest study published for this subject (12,455,361 adults), risk of death for all causes […]
In the first half of this presentation, I talk about my contribution to the gut-muscle axis in older adults, and in the second half, my personalized approach to optimal health! Also, here’s the article that corresponds to the presentation: https://www.leafscience.org/the-gut-microbiome-affects-muscle-strength-in-older-adults/ If you’re interested, please have a look at my book!
Can biological age be optimized? The red blood cell (RBC) distribution width (RDW%) is one of the variables included in the PhenoAge biological age calculator (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). Although the RDW% reference range is 11.5% – 14.5%, what values are optimal in terms a youthful biological age, and minimized disease risk? […]
In an earlier post, I wrote about quantifying my biological age with aging.ai (https://michaellustgarten.com/2018/06/26/maximizing-health-and-lifespan-is-calorie-restriction-essential/). The importance of that post is illustrated by the finding that based on data from 13 blood tests between 2016 – 2019, my average biological age is 29.2y, which is ~33% younger than my chronological age. […]
My goal is to break the world record for lifespan, 122 years, which is currently held by Jean Calment. How do I plan to do that? A good start would be calorie restriction (CR), a diet where you eat 10-30%+ less calories than your normal intake. CR is the gold […]