Monthly Archives: November 2021

Spermidine Impacts Health and Longevity

Join us on Patreon!

Papers referenced in the video:

Polyamine-rich food decreases age-associated pathology and mortality in aged mice

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats

Cardioprotection and lifespan extension by the natural polyamine spermidine

Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy

Higher spermidine intake is linked to lower mortality: a prospective population-based study

Polyamines in aging and disease

Dietary spermidine improves cognitive function

The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline

A review of dietary polyamines: Formation, implications forgrowth and health and occurrence in foods

In vitro digestion of spermidine and amino acids in fresh and processed Agaricus bisporus mushroom

Decrease in polyamines with aging and their ingestion from food and drink


How Many Steps Per Day Is Associated With Reduced Risk Of Death For All Causes?

Join us on Patreon!

Paper referenced in the video:

How many steps a day to reduce the risk of all-cause mortality? A dose–response meta-analysis

Physical Activity, Body Weight, And Diet Affect Resting Heart Rate And Heart Rate Variability

Join us on Patreon!

Papers referenced in the video:

Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults

Heart rate variability with photoplethysmography in 8 million individuals: a cross-sectional study

Metformin Impairs Exercise Training-Related Improvements In Older Adults

Join us on Patreon!

Papers referenced in the video:

Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a

Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults

Quantifying Biological Age: Blood Test #5 in 2021

Join us on Patreon!

Links to biological age calculators:

Levine’s PhenoAge calculator is embedded as an Excel file:

Papes referenced in the video:

Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies

Fisetin is a senotherapeutic that extends health and lifespan