Category Archives: Cholesterol

The Association For Low LDL With An Increased CVD Mortality Risk Is Impacted By Malnutrition

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Centenarian Blood Test Analysis (n=1,754)

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Papers referenced in the video:

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians

Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study

Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age

Age and sex variation in serum albumin concentration: an observational study

Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies

The gamma gap predicts 4-year all-cause mortality among nonagenarians and centenarians

Triglyceride centenarian studies are referenced in this post from my website:

Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults

VLDL Increases During Aging, And Is Associated With Adverse Cardiovascular Outcomes

Papers referenced in the video:

Remnant Cholesterol and Atherosclerotic Cardiovascular Disease Risk:…

The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling:…

Joint distribution of lipoprotein cholesterol classes. The Framingham study:

Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS):…

Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease:…

Remnant cholesterol and coronary atherosclerotic plaque burden assessed by computed tomography coronary angiography:…

Premature myocardial infarction is strongly associated with increased levels of remnant cholesterol:…

HDL Update: Age-Related Changes, All-Cause Mortality Risk, And Progress Towards The Optimal Range

In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis.

In addition, I’ve tested my HDL 2 more times since November 2020, so how’s my progress for getting it into the optimal range? Also, I attempt to derive clinical significance by identifying correlations for higher HDL with lower Lp(a) and hs-CRP.

Video link:

LDL Cholesterol: What’s Optimal For Health And Longevity?

LDL is arguably the most debated biomarker in terms of what’s optimal for health. In the video, I present data showing that 100 – 140, not 50 – 70 mg/dL may be optimal in terms of minimizing disease risk and maximizing longevity.

HDL: What’s Optimal For Minimizing Disease Risk And Maximizing Longevity?

Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 – 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video, I present data for 85y – 115yr olds that additionally suggests HDL in the 55 – 60 mg/dL range as optimal. In addition, I show my own HDL data over the past 15 years (n=34), the correlation for HDL with my diet, and how I plan on consistently increasing my 15-year average HDL of ~44 mg/dL to the 50’s.

Blood Test Analysis: 100 – 111y (Centenarians, Semi- and Super-Centenarians)

In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and super-centenarians (110y+).


Optimizing Blood Cholesterol Levels: What’s My Data?

In an earlier video, I presented data for total cholesterol (TC) levels in blood in terms of changes during aging and all-cause mortality risk. I’ve measured TC 25 times in the past 5 years, and in this video, I present that data, and my approach to optimize it.