Monthly Archives: March 2021

Telomere Length: How Does it Compare Against Other Biological Age Metrics?

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Papers referenced in the video:

The Hallmarks of Aging: https://www.ncbi.nlm.nih.gov/pmc/arti…​

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives: https://www.ncbi.nlm.nih.gov/pmc/arti…​

Telomeres and the natural lifespan limit in humans: https://www.ncbi.nlm.nih.gov/pmc/arti…​

Telomere Length and All-Cause Mortality: A Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/30254…​

Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999-2002: https://pubmed.ncbi.nlm.nih.gov/30999…​

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up: https://elifesciences.org/articles/51507​

Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing? https://pubmed.ncbi.nlm.nih.gov/29149…

HDL Update: Age-Related Changes, All-Cause Mortality Risk, And Progress Towards The Optimal Range

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In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis.

In addition, I’ve tested my HDL 2 more times since November 2020, so how’s my progress for getting it into the optimal range? Also, I attempt to derive clinical significance by identifying correlations for higher HDL with lower Lp(a) and hs-CRP.

Video link: https://www.youtube.com/watch?v=MUuKlpyvZaU

Carotenoids Are Associated With A Younger Epigenetic Age And Reduced All-Cause Mortality Risk

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Papers referenced in the video: DNA methylation

GrimAge strongly predicts lifespan and healthspan:

https://pubmed.ncbi.nlm.nih.gov/30669…​

GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality:

https://pubmed.ncbi.nlm.nih.gov/33211…​

Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies: https://pubmed.ncbi.nlm.nih.gov/30475…​

Albumin is included as a biological age predictor:

https://www.ncbi.nlm.nih.gov/pmc/arti…​

https://www.ncbi.nlm.nih.gov/pmc/arti…​

https://www.ncbi.nlm.nih.gov/pmc/arti…​

https://pubmed.ncbi.nlm.nih.gov/30993…​

Age-related change data for albumin:

https://pubmed.ncbi.nlm.nih.gov/26071…​

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages: https://www.nature.com/articles/s4146…

Quantifying Biological Age: Blood Test #1 in 2021

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Results for my first blood test in 2021 are in-what’s my biological age, and how am I optimizing it?

If you’re interested in calculating your biological age, the spreadsheet is included as an Excel file in this link:

Quantifying Biological Age