Category Archives: FGF21

Methionine Restriction Extends Lifespan: Roles For SCFAs And FGF21, But Not Calorie Restriction

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Papers referenced in the video:
Dietary Methionine via Dose-Dependent Inhibition of Short-Chain Fatty Acid Production Capacity Contributed to a Potential Risk of Cognitive Dysfunction in Mice
https://pubmed.ncbi.nlm.nih.gov/36413479/

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age
https://pubmed.ncbi.nlm.nih.gov/19414512/

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice
https://pubmed.ncbi.nlm.nih.gov/31195972/

Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
https://pubmed.ncbi.nlm.nih.gov/15924568/

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
https://pubmed.ncbi.nlm.nih.gov/24245565/

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
https://pubmed.ncbi.nlm.nih.gov/23066506/

High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?

Papers referenced in the video:

FGF21 and Chronic Kidney Disease: https://www.sciencedirect.com/science…

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21: https://pubmed.ncbi.nlm.nih.gov/18585…

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877…

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression: https://pubmed.ncbi.nlm.nih.gov/31773…

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses: https://pubmed.ncbi.nlm.nih.gov/28552…

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging: https://pubmed.ncbi.nlm.nih.gov/33131…

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue: https://pubmed.ncbi.nlm.nih.gov/30043…

Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals: https://pubmed.ncbi.nlm.nih.gov/26042…

Lower All-Cause, Cardiovascular, and Cancer Mortality in Centenarians’ Offspring: https://pubmed.ncbi.nlm.nih.gov/15571…

Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study: https://pubmed.ncbi.nlm.nih.gov/20398…