Papers referenced in the video: Sirtuins, Healthspan, and Longevity in Mammals… Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH… Resveratrol improves health and survival of mice on a high-calorie diet… Rapamycin, But Not Resveratrol […]

Papers referenced in the video: Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence:… NAD and the aging process: Role in life, death and everything in between:… Flavonoids as inhibitors of human CD38:… Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ […]

Papers referenced in the video: Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism: Aerobic and resistance exercise training reverses age-dependent decline in NAD + salvage capacity in human skeletal muscle:

LPS increases during aging, which may explain the age-related increase for CD38 and decreased NAD+. LPS is decreased on a calorie restricted diet, but what else can reduce it? In this video, I present evidence for intestinal alkaline phosphatase’s (IAP) role on LPS, and posit that interventions that increase IAP […]

Many interventions have been reported to increase NAD levels, but dietary components that can impact NAD levels are less discussed. Here, I highlight the ability of two dietary components, apigenin and quercetin to increase NAD, and report the foods that contain these metabolites.