Category Archives: Microbes/Microbial Products Affect The Hallmarks Of Aging

Siim Land Podcast #2: Impact Of Microbes On Aging And Age-Related Disease

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Bacteria From An Olympic Weightlifter Improves Muscle Mass And Physical Function (In Mice)

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CONQUERAGING!
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Paper referenced in the video:
Probiotic Lactiplantibacillus plantarum Tana Isolated from an International Weightlifter Enhances Exercise Performance and Promotes Antifatigue Effects in Mice
https://pubmed.ncbi.nlm.nih.gov/36014816/

A Bile Acid (TBMCA) Is Involved In A Mechanism That Reduces Muscle Mass And Strength

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Papers referenced in the video:

Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling https://pubmed.ncbi.nlm.nih.gov/33783283/

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist https://pubmed.ncbi.nlm.nih.gov/23395169/

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice https://pubmed.ncbi.nlm.nih.gov/28650457/

Gut Bacteria Boost Host NAD Metabolism

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Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130883/

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism: https://pubmed.ncbi.nlm.nih.gov/27304511/

Aerobic and resistance exercise training reverses age-dependent decline in NAD + salvage capacity in human skeletal muscle: https://pubmed.ncbi.nlm.nih.gov/31207144/