Papers referenced in the video: Remnant Cholesterol and Atherosclerotic Cardiovascular Disease Risk: https://www.jacc.org/doi/10.1016/j.ja… The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling: https://www.sciencedirect.com/science… Joint distribution of lipoprotein cholesterol classes. The Framingham study: https://pubmed.ncbi.nlm.nih.gov/6573877/ Long-term […]

In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis. In addition, I’ve tested my HDL […]

The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes. Viruses, including SARS-CoV-2 and HSV-1 cause mitochondrial dysfunction-more specifically, they cause mitochondria to release some of their DNA, which triggers antiviral immunity. When considering that blood levels of mitochondrial DNA increase during aging, […]

In an earlier video, I presented data for apigenin’s ability to increase levels of NAD+. In addition to apigenin’s impact on NAD+, apigenin supplementation increases muscle mass, strength, and treadmill running distance in both young and old mice. Video link for NAD+ is increased in response to apigenin: https://youtu.be/5-2YoGctcCk?list=UUT… Paper […]

Here’s an interview that I did with Richard at Modern Healthspan, one of the best interviewers in aging! Part I: Monitoring Biomarkers to Reverse Aging: Part II, Diet, CR & Fasting: Part III: Exercise, Protein Part IV: Optimize Nutrients Through Diet Part V: Inhibit CD38 to Optimize NAD Part VI: […]

In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and […]

Blood urea nitrogen (BUN) is one of the 19 variables found on the biological age calculator, aging.ai. It measures the amount of nitrogen, as contained in urea (i.e., blood urea nitrogen, BUN) in your blood. The reference range for BUN is 5 – 20 mg/dL, but within that range, what’s […]

Many interventions have been reported to increase NAD levels, but dietary components that can impact NAD levels are less discussed. Here, I highlight the ability of two dietary components, apigenin and quercetin to increase NAD, and report the foods that contain these metabolites.

Most often overlooked on a standard blood test are the mean corpuscular volume (MCW) and Red Blood Cell Distribution Width (RDW). How do they change during aging, and what’s associated with all-cause mortality risk? Also, with the goal of optimizing MCV and RDW, how does my diet correlate with these […]

In the first half of this presentation, I talk about my contribution to the gut-muscle axis in older adults, and in the second half, my personalized approach to optimal health! Also, here’s the article that corresponds to the presentation: https://www.leafscience.org/the-gut-microbiome-affects-muscle-strength-in-older-adults/ If you’re interested, please have a look at my book!