Category Archives: Video

Resting Heart Rate And Heart Rate Variability: What’s Optimal, 1,502 Days of Data

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Papers referenced in the video:
Biological aging of human body and brain systems
https://www.medrxiv.org/content/10.1101/2022.09.03.22279337v1

Relation of high heart rate variability to healthy longevity
https://pubmed.ncbi.nlm.nih.gov/20381674/

Heart Rate Variability and Exceptional Longevity
https://pubmed.ncbi.nlm.nih.gov/33041862/

Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults
https://pubmed.ncbi.nlm.nih.gov/32023264/

Heart rate variability with photoplethysmography in 8 million individuals: a cross-sectional study
https://pubmed.ncbi.nlm.nih.gov/33328029/

Blood Test #5 in 2022: Supplements, Diet

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Papers referenced in the video:
Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies
https://pubmed.ncbi.nlm.nih.gov/31069230/

Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey
https://pubmed.ncbi.nlm.nih.gov/10075334/

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians
https://pubmed.ncbi.nlm.nih.gov/31908434/

DHEA-S Is A Weakness In My Data: Blood Test #5 in 2022

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Papers referenced in the video:
Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults
https://pubmed.ncbi.nlm.nih.gov/30733566/

The Value of Serum Albumin and High-Density Lipoprotein Cholesterol in Defining Mortality Risk in Older Persons with Low Serum Cholesterol
https://pubmed.ncbi.nlm.nih.gov/11559371/

Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives
https://pubmed.ncbi.nlm.nih.gov/31201927/

Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas
https://pubmed.ncbi.nlm.nih.gov/32751564/

Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow up study in a community based cohort (Tanushimaru study)
https://pubmed.ncbi.nlm.nih.gov/18422949/

Quantifying Biological Age: Blood Test #5 in 2022

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Papers referenced in the video:
A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
https://pubmed.ncbi.nlm.nih.gov/30596641/

Underlying features of epigenetic aging clocks in vivo and in vitro
https://pubmed.ncbi.nlm.nih.gov/32930491/

Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants
https://pubmed.ncbi.nlm.nih.gov/33684206/

Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations
https://pubmed.ncbi.nlm.nih.gov/29340580/

The Excel file to calculate Levine’s Biological Age is embedded in this link from my website:
https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

Ending Age-Related Diseases 2022 Conference Presentation

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Glycine + N-Acetyl Cysteine Supplementation Increases Lifespan

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Paper referenced in the video:
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/35975308/

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in
Mice Increases Length of Life by Correcting Glutathione
Deficiency, Oxidative Stress, Mitochondrial Dysfunction,
Abnormalities in Mitophagy and Nutrient Sensing,
and Genomic Damage
https://pubmed.ncbi.nlm.nih.gov/35268089/

Glycine and N-acetylcysteine (GlyNAC) supplementation in
older adults improves glutathione deficiency, oxidative
stress, mitochondrial dysfunction, inflammation, insulin
resistance, endothelial dysfunction, genotoxicity, muscle
strength, and cognition: Results of a pilot clinical trial
https://pubmed.ncbi.nlm.nih.gov/33783984/

Biohacking the Oral Microbiome

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Papers referenced in the video:
Interconnections Between the Oral and Gut Microbiomes: Reversal of Microbial Dysbiosis and the Balance Between Systemic Health and Disease https://pubmed.ncbi.nlm.nih.gov/33652903/

A Brief Introduction to Oral Diseases: Caries, Periodontal Disease, and Oral Cancer
https://tinyurl.com/z45d6djt

Xylitol, mutans streptococci, and dental plaque
https://pubmed.ncbi.nlm.nih.gov/19717413/

Growth Inhibition of Streptococcus mutans with Low Xylitol Concentrations
https://pubmed.ncbi.nlm.nih.gov/18176823/

The antimicrobial activity of essential oils and essential oil components towards oral bacteria https://pubmed.ncbi.nlm.nih.gov/7478759/

Nitrate as a potential prebiotic for the oral microbiome
https://pubmed.ncbi.nlm.nih.gov/32732931/

A Bile Acid (TBMCA) Is Involved In A Mechanism That Reduces Muscle Mass And Strength

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Papers referenced in the video:

Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling https://pubmed.ncbi.nlm.nih.gov/33783283/

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist https://pubmed.ncbi.nlm.nih.gov/23395169/

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice https://pubmed.ncbi.nlm.nih.gov/28650457/

Bile Acids: The Next Frontier In Longevity?

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Papers referenced in the video:

Glycine supplementation extends lifespan of male and female mice https://pubmed.ncbi.nlm.nih.gov/30916479/

Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation https://pubmed.ncbi.nlm.nih.gov/34877949/

17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex https://pubmed.ncbi.nlm.nih.gov/33788371/

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors https://www.nature.com/articles/s43587-022-00193-0

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism https://pubmed.ncbi.nlm.nih.gov/30157432/

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production https://pubmed.ncbi.nlm.nih.gov/11371619/

Alterations in xenobiotic metabolism in the long-lived Little mice https://pubmed.ncbi.nlm.nih.gov/17521389/ Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age https://pubmed.ncbi.nlm.nih.gov/19414512/

Bile Acids: A Communication Channel in the Gut-Brain Axis https://pubmed.ncbi.nlm.nih.gov/33085065/

Resting Heart Rate And Heart Rate Variability: What’s Optimal, 4-Year Progress

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Papers referenced in the video: Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults https://pubmed.ncbi.nlm.nih.gov/32023264/

Heart rate variability with photoplethysmography in 8 million individuals: a cross-sectional study https://pubmed.ncbi.nlm.nih.gov/33328029/