Besides diet (https://michaellustgarten.com/2019/12/07/slowing-epigenetic-aging-with-diet/), are there other factors that may impact epigenetic aging? First, let’s have a look at clinically relevant variables, including inflammation, the lipid profile, kidney function, blood pressure, and body size/dimensions (Liu et al. 2019): One of the strongest correlations for the clinical variables with epigenetic aging (AgeAccelGrim) […]
Having a faster rate of epigenetic aging, as measured by the epigenetic age metric, AgeAccelGrim, is associated with a significantly increased risk of death for all causes in a variety of cohorts, including the Framingham Heart Study (FHS), the Women’s Health Initiative (WHI) study, the InChianti study, the Jackson Heart […]
Although many of my posts aimed at improving health and longevity are focused on diet, in this post I’ll show data that demonstrates that I’ve been able to steadily improve my cardiovascualr fitness. In earlier posts I reported that a resting heart rate (RHR) of 40 beats per minute (bpm) […]
Three studies have investigated the ability of blood test analytes to predict biological age. First, when considering the top 20 variables that were associated with biological age in aging.ai, albumin contributed most to this prediction, almost 2x more than circulating levels of glucose (Mamoshina et al. 2018): Second, albumin was […]
To make it easier to review the aging and all-cause mortality data for the circulating biomarkers that are contained within the biological age calculator, Phenotypic Age (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/), here’s a checklist! 1. Albumin: https://michaellustgarten.com/2019/09/22/optimizing-serum-levels-of-albumin-data-from-20-blood-tests/ 2. Creatinine: https://michaellustgarten.com/2019/11/18/optimizing-biologic-age-creatinine/ 3. Glucose: https://michaellustgarten.com/2019/10/04/blood-glucose-whats-optimal/ 4. C-reactive protein: https://michaellustgarten.com/2019/10/19/optimizing-biological-age-crp/ 5. Lymphocyte %: https://michaellustgarten.com/2019/11/16/lympho-mortal/ 6. Mean […]
Creatinine is one of the 9 blood test variables included on the biological age calculator, Phenotypic Age (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). The reference range for women and men is 0.5 – 1.1, and 0.6 – 1.2 mg/dL respectively, but within that range, what’s optimal for health and longevity? To answer that question, it’s […]
The percentage of lymphocytes is one of the 9 blood test variables included in the biological age calculator, Phenotypic Age (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). The reference range for lymphocyte % is 20 – 40% of the total amount of white blood cells (WBCs), but are higher or lower values optimal for health and […]
My average biological age in 2019 is 12 years younger than my chronological age (46y) based on the Phenotypic Age calculator (https://michaellustgarten.com/2019/11/01/biological-age-31-3y-chronological-age-46y/), and 16y younger based on aging.ai (https://michaellustgarten.com/2019/11/04/years-of-biological-aging-in-the-past-4-years/). One factor that likely contributes to my relatively youthful biological age is my diet. Shown below is my average daily dietary […]
In an earlier post (https://michaellustgarten.com/2018/06/26/maximizing-health-and-lifespan-is-calorie-restriction-essential/), I documented my aging.ai biologic age for 13 blood test measurements from 2016 – 2019. If you missed that post, here are those data: Note that note my average biologic age has slowly increased from 2016 to 2019, from 28y in 2016 (2 measurements), to […]
On June 10, 2019 (for the first time) I measured all of the blood test variables that are included in the biologic age calculator, Phenotypic Age, and ended up with a biological age = 35.39y (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). While that value is 23% younger than my chronological age (46y), I knew that […]
Platelets are one of the 19 variables that are included in the biological age calculator, aging.ai. The reference range is 150-400 platelets per nanoliter (*10^9/L), but within that range, what’s optimal? In a study of 21,635 adults older than 35y (average age wasn’t reported), platelets between 230-270 were associated with […]
The coronary artery calcification (CAC) score is a measure of how much calcification is in the coronary arteries, and accordingly, is an in vivo measure of atherosclerosis. Why is the CAC score important? Besides its role in atherosclerosis, risk of death for all causes goes up at any age as the […]
High sensitivity C-Reactive Protein (CRP) is one of the 10 variables included in the biological age calculator, PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). The reference range for CRP is 0 – 3 mg/L, but within that range, what’s optimal? To answer that question, it’s important to know how CRP changes during aging, and what […]
Mean corpuscular volume (MCV) is one of the 10 variables included in the biological age calculator, PhenoAge (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). It’s calculated by dividing the fraction of the blood that contains RBCs (hematocrit) by RBCs (MCV = hematocrit/RBC), thereby identifying the average volume contained within red blood cells. Although the MCV reference […]
Circulating levels of white blood cells (WBCs) are one of the 10 variables used to quantify biological age with PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age). The reference range for WBCs is 4.5 – 11 *10^9 cells/L, but within that range, what’s optimal? Several studies have reported that WBCs greater than 5 are associated with […]
In an earlier post, based on data from the Baltimore Longitidunal Study on Aging (BLSA), I suggested that total white blood cell (WBCs) counts between 3500 to 6000 cells per microliter of blood may be optimal for reducing disease risk and for maximizing longevity (https://michaellustgarten.com/2015/08/13/blood-testing-whats-optimal-for-wbc-levels/). However, within WBCs, neutrophils increase, […]
A few months ago, I presented data that a resting heart rate (RHR) ~40 beats per min is associated with maximally reduced risk of death from all causes (https://michaellustgarten.com/2019/02/02/resting-heart-rate-whats-optimal/). I started tracking my RHR data in August 2018, and I now have more than a full year of data. RHR […]
Alkaline phosphatase (ALP) is one of the 10 variables used to quantify biological age with PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age). The reference range for alkaline phosphatase is 20 – 140 IU/L*, but within that range, what’s optimal? Two separate meta-analyses have investigated the association between serum levels of ALP with risk of death […]
The reference range for circulating levels of glucose is 70-130 mg/dL. That’s a wide range, so what’s optimal, especially considering that glucose is one of the variables used to quantify of biological age (https://michaellustgarten.com/2019/09/09/quantifying-biological-age)? In the largest study published for this subject (12,455,361 adults), risk of death for all causes […]
In the first half of this presentation, I talk about my contribution to the gut-muscle axis in older adults, and in the second half, my personalized approach to optimal health! Also, here’s the article that corresponds to the presentation: https://www.leafscience.org/the-gut-microbiome-affects-muscle-strength-in-older-adults/ If you’re interested, please have a look at my book!
Following five lifestyle-related factors is associated with a gain in average life expectancy (Li et al. 2018). What are these factors? Not smoking, having a BMI between 18.5 to 24.9 kg/m2, engaging in more than 30 minutes of moderate to vigorous physical activity (at a minimum, walking ~3 miles per hour; 30 […]
Can biological age be optimized? The red blood cell (RBC) distribution width (RDW%) is one of the variables included in the PhenoAge biological age calculator (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). Although the RDW% reference range is 11.5% – 14.5%, what values are optimal in terms a youthful biological age, and minimized disease risk? […]
In an earlier post, I showed published data that albumin levels decrease with aging, and that lower levels are associated with an increased all-cause mortality risk (https://michaellustgarten.com/2018/07/06/serum-albumin-and-acm/). I also showed my own blood test data (n=11), which included a strong correlation for albumin with my dietary intake of beta-carotene (r = […]
Have a listen, I was on Generation Bold Radio yesterday, 9.14.2019! https://www.generationboldradio.us/
Is green tea consumption associated with reduced risk of death risk from all causes? To investigate this question, Tang et al. (2015) performed a meta-analysis of 5 studies, including 200,884 subjects. As shown below, drinking 2-3 cups (16-24 oz.) of green tea per day was associated with maximally decreased all-cause mortality risk, […]
In an earlier post, I wrote about quantifying my biological age with aging.ai (https://michaellustgarten.com/2018/06/26/maximizing-health-and-lifespan-is-calorie-restriction-essential/). The importance of that post is illustrated by the finding that based on data from 13 blood tests between 2016 – 2019, my average biological age is 29.2y, which is ~33% younger than my chronological age. […]
Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults https://www.sciencedirect.com/science/article/pii/S0531556519304772
Circulating levels of calcium can deposit in the coronary arteries (and in other arterial sites), a process that is known as coronary artery calcification (CAC). Arterial calcification is associated with arterial stiffness, which increases risk for adverse cardiovascular events, including cardiovascular disease-related mortality (Allison et al. 2012). Can CAC accumulation be slowed/minimized/prevented? […]
Very low, low, and high-density lipoproteins (VLDL, LDL, HDL, respectively) are commonly measured on the standard blood chemistry panel as measures of cardiovascular disease risk. Not included on that panel is another lipoprotein, Lp(a), which is a modified form of LDL. What’s the relationship between Lp(a) with disease risk? A […]
It could go either way for Tesla in Q2 2019 to generate a profit or a loss. Let’s have a look at the data! By now, almost everyone knows that Tesla had a record quarter for deliveries (95,220), including 17,650 Model S+X, and 77,550 Model 3’s. More importantly, Tesla decreased […]
Microbiome Webinar featuring me, and Drs. Amy Proal and Cosmo Mielke! For more info, https://www.amazon.com/dp/B01G48A88A
Deep sleep, the stage of sleep also known as “slow wave sleep” declines during aging. Based on a meta-analysis of 65 studies representing 3,577 subjects (aged 5 years to 102 years; Ohayon et al. 2004), slow wave sleep, expressed as a percentage of total sleep time decreases during aging from 25% […]
I’ve posted individual dietary days as an example of what and how much I eat (https://michaellustgarten.com/2015/12/31/130-grams-of-fiber-2400-calories/). However, a few days of examples may not represent the whole dietary picture. To address this, below is my average nutrient intake for the past 100 days (from October 24, 2018-Feb 5 2019): Notice […]
To learn more, please have a look at my book!
One of the goals of my exercise program is to reduce my resting heart rate (RHR). A stronger heart beats less times per minute, but pumps more blood per beat. In contrast, a weaker heart beats more times per minute, but less blood per beat. Is there an optimal level […]
Tufts Nutrition Magazine, 1/2019 Please have a look at my book, if you’re interested!
With use of a food scale, I’ve been tracking my daily macro- and micronutrient intake every day since April 2015. In addition, I have 15 blood test measurements during that period, and accordingly, I’m able to examine correlations between my dietary intake with my circulating biomarkers. In this post, I’ll […]
Levels of serum albumin peak at about 20 years old (~4.6 g/dL for males, ~4.4 g/dL for females), then decrease during aging, as shown for the 1,079,193 adults of Weaving et al. (2016): Similar age-related decreases for serum albumin albumin have also been reported in smaller studies: Gom et al. 2007 (62,854 […]
My goal is to break the world record for lifespan, 122 years, which is currently held by Jean Calment. How do I plan to do that? A good start would be calorie restriction (CR), a diet where you eat 10-30%+ less calories than your normal intake. CR is the gold […]
Sean Manaea threw a no-hitter last night, against arguably one of the best lineups in baseball. Post-no-hitter, the question is whether Manaea will ascend into becoming an elite starting pitcher, or will be go the way of pitchers like Philip Humber and Homer Bailey, who also threw a no-hitters, but […]
In an earlier post I wrote about the association between elevated circulating levels of homocysteine with an increased risk of death from all causes (https://michaellustgarten.com/2017/11/22/homocysteine-and-all-cause-mortality-risk/). I started to post updates in that link, but I’ve decided to move them to here. As of 6/2018, I now have tracked dietary data […]
Paper #1: Here I propose that the poor muscle composition (muscle that has fat in it) found in older adults may be related to an increased systemic microbial burden: https://www.ncbi.nlm.nih.gov/pubmed/29030163 Paper #2: In this review, we discuss the emerging gut-muscle axis: https://www.ncbi.nlm.nih.gov/pubmed/29058056 If you’re interested, please have a […]
On a recent blood test, my plasma level of homocysteine (Hcy) was 11.9 uMol. Is that optimal minimizing disease risk and maximizing longevity? Let’s have a look at the literature. A 2017 meta-analysis of 11 studies including 27,737 participants showed an increased risk of death from all causes (“all-cause mortality”; […]
Yesterday, mlb.com released its “Who will be the top 10 prospects a year from now” list. First, it’s important to define some criteria. To be considered as a “prospect”, the player must not have played in MLB. With that in mind, at best, I agree with only 2 of the […]
If you’re interested, please have a look at my book!
http://www.leafscience.org/dr-michael-lustgarten-using-an-evidence-based-approach-for-optimal-health-and-longevity/ If you’re interested, please have a look at my book!
I recently had food allergy testing performed. Here are my results! If you’re interested, please have a look at my book!