What’s The Best Way To Optimize NAD? Jin-Xiong She, PhD

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7 thoughts on “What’s The Best Way To Optimize NAD? Jin-Xiong She, PhD”

  1. Ole Bisgaard Pedersen's avatarOle Bisgaard Pedersen

    Hi Michael,

    Perhaps it would be sufficient to restore NAMPT activity instead of supplementing with high dose nicotinamide, which causes issues with 2py/4py

    Study in mice shows that nanograms of nicotine effectively restore NAMPT activity to a youthfull level. EGCG, raw cacao, cranberry and blueberries show the same effect although not as powerful as nicotine

    Perhaps a combination of CD38 inhibitors (apigenin and quercetin) with low dose nicotine chewing gum or nicotine patch.

    In addition nicotine apparently has neuroprotective as nicotine consumption is correlated with a lower risk of developing e.g. PD

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    1. Michael Lustgarten's avatarMichael Lustgarten Post author

      Interesting, thanks Ole. Nicotine is directly converted into nicotinic acid (NA), which would likely be the better approach to limit 2PY and 4PY, relative to nicotinamide-based precursors, as they’re directly converted into those metabolites.

      Also, use of NA gets around an age-related NAMPT decline…

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  2. James's avatarJames

    Hello Mike

    Are there any alternative payment methods than patreon?

    I am interested in a 12m or lifetime sub(if exists).

    I noticed patreon allows publishers to gift memership, Could I not pay you via Bitcoin/crypto or Amazon gift card… etc and you can then gift the membership via the patreon?

    Feel free to delete this post once you have read it, I will leave my email below.

    regards

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  3. James's avatarJames

    Additionally, I wanted to learn your own personal vitamin / mineral stack, which package would be best suited for that?

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  4. Ole Bisgaard Pedersen's avatarOle Bisgaard Pedersen

    Its interessting that Jin-Xiong She only highlights the risk concerning high dose niacin use, but complete fails to mention the invetiable accumulatiion of 2py and 4py from using VitalityBoost+.

    Using 500mg of NAM and 500mg of NMN will cause accumulation of dangeroulsy high plasma levels of 2py and 4py. I don’t think anyone should go higher than 250mg of NMN or NAM per day for long term use.

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