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Part II: Use Of Machine Learning In Longevity Science: A Conversation With Dr. Michael Rose Part III: Which Diet Is Optimal For Health: The Evolutionary Perspective Full, 80-minute, unedited video: Papers referenced in the videos: Can human aging be postponed? https://pubmed.ncbi.nlm.nih.gov/10614072/ Paper referenced in the video: Diet and Botanical Supplementation: […]
Papers referenced in the video: Loss of Life Expectancy by 10 Years or More From Elevated Aspartate Aminotransferase: Finding Aspartate Aminotransferase a Better Mortality Predictor for All-Cause and Liver-Related than Alanine Aminotransferase https://pubmed.ncbi.nlm.nih.gov/31425… Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study https://pubmed.ncbi.nlm.nih.gov/29491…
HOMA calculator: https://www.omnicalculator.com/health… Papers referenced in the video: Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice https://pubmed.ncbi.nlm.nih.gov/24175… Glucose regulation and oxidative stress in healthy centenarians https://pubmed.ncbi.nlm.nih.gov/12543… Distribution of blood glucose and prevalence of diabetes among centenarians and oldest-old in China: based on the China […]
Papers referenced in the video: Sirtuins, Healthspan, and Longevity in Mammals https://www.sciencedirect.com/science… Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH https://pubmed.ncbi.nlm.nih.gov/24011… Resveratrol improves health and survival of mice on a high-calorie diet https://pubmed.ncbi.nlm.nih.gov/17086… Rapamycin, But Not Resveratrol […]
Papers referenced in the video: FGF21 and Chronic Kidney Disease: https://www.sciencedirect.com/science… The starvation hormone, fibroblast growth factor-21, extends lifespan in mice: https://www.ncbi.nlm.nih.gov/pmc/arti… Inhibition of growth hormone signaling by the fasting-induced hormone FGF21: https://pubmed.ncbi.nlm.nih.gov/18585… Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877… Berberine ameliorates cellular senescence […]
Papers referenced in the video: Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence: https://pubmed.ncbi.nlm.nih.gov/29514… NAD and the aging process: Role in life, death and everything in between: https://pubmed.ncbi.nlm.nih.gov/27825… Flavonoids as inhibitors of human CD38: https://pubmed.ncbi.nlm.nih.gov/21641… Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ […]
Paper references for Levine’s Phenotypic Age calculator and aging.ai: An epigenetic biomarker of aging for lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/29676… Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations: https://pubmed.ncbi.nlm.nih.gov/29340…
Papers referenced int the video: Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation: https://pubmed.ncbi.nlm.nih.gov/21795… Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: […]
Papers referenced in the video: Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130883/ CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism: https://pubmed.ncbi.nlm.nih.gov/27304511/ Aerobic and resistance exercise training reverses age-dependent decline in NAD + salvage capacity in human skeletal muscle: https://pubmed.ncbi.nlm.nih.gov/31207144/
Papers referenced in the video: The Hallmarks of Aging: https://www.ncbi.nlm.nih.gov/pmc/arti… Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives: https://www.ncbi.nlm.nih.gov/pmc/arti… Telomeres and the natural lifespan limit in humans: https://www.ncbi.nlm.nih.gov/pmc/arti… Telomere Length and All-Cause Mortality: A Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/30254… Comparability of biological aging measures in the National […]
Papers referenced in the video: DNA methylation GrimAge strongly predicts lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/30669… GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality: https://pubmed.ncbi.nlm.nih.gov/33211… Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic […]
Results for my first blood test in 2021 are in-what’s my biological age, and how am I optimizing it? If you’re interested in calculating your biological age, the spreadsheet is included as an Excel file in this link:
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes. Viruses, including SARS-CoV-2 and HSV-1 cause mitochondrial dysfunction-more specifically, they cause mitochondria to release some of their DNA, which triggers antiviral immunity. When considering that blood levels of mitochondrial DNA increase during aging, […]
The maximal reduction for biological age when using the biological age calculator, Phenotypic Age, is ~20 years. In other words, if I’m 80 years old and my biomarkers are all reflective of youth, the lowest possible biological age will be ~60 years old. One reason for that is the inclusion […]
In an earlier video, I presented data for apigenin’s ability to increase levels of NAD+. In addition to apigenin’s impact on NAD+, apigenin supplementation increases muscle mass, strength, and treadmill running distance in both young and old mice. Video link for NAD+ is increased in response to apigenin: https://youtu.be/5-2YoGctcCk?list=UUT… Paper […]
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.
LDL is arguably the most debated biomarker in terms of what’s optimal for health. In the video, I present data showing that 100 – 140, not 50 – 70 mg/dL may be optimal in terms of minimizing disease risk and maximizing longevity.
White blood cells (WBCs) comprise many different cell types, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Neutrophils, lymphocytes, and monocytes account for ~99% of WBCs, and accordingly, in the video I propose optimal ranges for these cell types in terms of health and longevity.
Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 – 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video, I present data for 85y – 115yr olds that additionally suggests HDL in the 55 – 60 mg/dL range […]
Animal products, including meat, cheese, and eggs contain carnitine and choline, metabolites that are converted by gut bacteria into TMA, which is then converted by the liver into TMAO. Plasma levels of TMAO are associated with an increased risk of disease and death, so should we limit intake of these […]
A reduced mortality risk and an increased lifespan has been reported for people who have APOE2 alleles, when compared with APOE3 or APOE4, but beyond associations, data for lifespan in APOE-expressing mice was recently reported, evidence that supports a causative role for APOE on longevity.
My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them with diet going forward.
After going on Joe Rogan’s podcast, Paul Saladino, MD, posted his show notes, which included his blood test results. Based on that data, is his biological age optimal while on a carnivore diet?
Here’s a podcast that was recorded with WildHealth, enjoy!
The incidence of fungi bloodstream infections increases during aging-is that a potential explanation for the presence of fungi in the brains of Alzheimer’s disease patients? Rapamycin is a known antifungal-is it effective against fungi that are found in the blood and brain?
Maximal lifespan in calorie restricted (CR) mice can range from 45 – 55 months. In this video, I present data for 3 studies on rapamycin-can it beat CR for maximal lifespan?
LPS increases during aging, which may explain the age-related increase for CD38 and decreased NAD+. LPS is decreased on a calorie restricted diet, but what else can reduce it? In this video, I present evidence for intestinal alkaline phosphatase’s (IAP) role on LPS, and posit that interventions that increase IAP […]
My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them going forward.
Blood urea nitrogen (BUN) is one of the 19 variables found on the biological age calculator, aging.ai. It measures the amount of nitrogen, as contained in urea (i.e., blood urea nitrogen, BUN) in your blood. The reference range for BUN is 5 – 20 mg/dL, but within that range, what’s […]
Although many of my posts aimed at improving health and longevity are focused on diet, in this post I’ll show data that demonstrates that I’ve been able to steadily improve my cardiovascualr fitness. In earlier posts I reported that a resting heart rate (RHR) of 40 beats per minute (bpm) […]
To make it easier to review the aging and all-cause mortality data for the circulating biomarkers that are contained within the biological age calculator, Phenotypic Age (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/), here’s a checklist! 1. Albumin: https://michaellustgarten.com/2019/09/22/optimizing-serum-levels-of-albumin-data-from-20-blood-tests/ 2. Creatinine: https://michaellustgarten.com/2019/11/18/optimizing-biologic-age-creatinine/ 3. Glucose: https://michaellustgarten.com/2019/10/04/blood-glucose-whats-optimal/ 4. C-reactive protein: https://michaellustgarten.com/2019/10/19/optimizing-biological-age-crp/ 5. Lymphocyte %: https://michaellustgarten.com/2019/11/16/lympho-mortal/ 6. Mean […]
The percentage of lymphocytes is one of the 9 blood test variables included in the biological age calculator, Phenotypic Age (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). The reference range for lymphocyte % is 20 – 40% of the total amount of white blood cells (WBCs), but are higher or lower values optimal for health and […]
My average biological age in 2019 is 12 years younger than my chronological age (46y) based on the Phenotypic Age calculator (https://michaellustgarten.com/2019/11/01/biological-age-31-3y-chronological-age-46y/), and 16y younger based on aging.ai (https://michaellustgarten.com/2019/11/04/years-of-biological-aging-in-the-past-4-years/). One factor that likely contributes to my relatively youthful biological age is my diet. Shown below is my average daily dietary […]
In an earlier post (https://michaellustgarten.com/2018/06/26/maximizing-health-and-lifespan-is-calorie-restriction-essential/), I documented my aging.ai biologic age for 13 blood test measurements from 2016 – 2019. If you missed that post, here are those data: Note that note my average biologic age has slowly increased from 2016 to 2019, from 28y in 2016 (2 measurements), to […]
On June 10, 2019 (for the first time) I measured all of the blood test variables that are included in the biologic age calculator, Phenotypic Age, and ended up with a biological age = 35.39y (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). While that value is 23% younger than my chronological age (46y), I knew that […]
High sensitivity C-Reactive Protein (CRP) is one of the 10 variables included in the biological age calculator, PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). The reference range for CRP is 0 – 3 mg/L, but within that range, what’s optimal? To answer that question, it’s important to know how CRP changes during aging, and what […]
In an earlier post, based on data from the Baltimore Longitidunal Study on Aging (BLSA), I suggested that total white blood cell (WBCs) counts between 3500 to 6000 cells per microliter of blood may be optimal for reducing disease risk and for maximizing longevity (https://michaellustgarten.com/2015/08/13/blood-testing-whats-optimal-for-wbc-levels/). However, within WBCs, neutrophils increase, […]
A few months ago, I presented data that a resting heart rate (RHR) ~40 beats per min is associated with maximally reduced risk of death from all causes (https://michaellustgarten.com/2019/02/02/resting-heart-rate-whats-optimal/). I started tracking my RHR data in August 2018, and I now have more than a full year of data. RHR […]
Alkaline phosphatase (ALP) is one of the 10 variables used to quantify biological age with PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age). The reference range for alkaline phosphatase is 20 – 140 IU/L*, but within that range, what’s optimal? Two separate meta-analyses have investigated the association between serum levels of ALP with risk of death […]
Very low, low, and high-density lipoproteins (VLDL, LDL, HDL, respectively) are commonly measured on the standard blood chemistry panel as measures of cardiovascular disease risk. Not included on that panel is another lipoprotein, Lp(a), which is a modified form of LDL. What’s the relationship between Lp(a) with disease risk? A […]
Levels of serum albumin peak at about 20 years old (~4.6 g/dL for males, ~4.4 g/dL for females), then decrease during aging, as shown for the 1,079,193 adults of Weaving et al. (2016): Similar age-related decreases for serum albumin albumin have also been reported in smaller studies: Gom et al. 2007 (62,854 […]
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Two blood markers of liver health are aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT). AST and ALT are proteins that are usually found inside liver cells, but when there is liver cell damage, they’re released into the blood. It’s important to note that these proteins can also be elevated in the […]