Tag Archives: aging

Longitudinal Biomarker Optimization: A Road To Maximize Health And Longevity?

Dietary Fiber And SCFAs Are Relatively Higher in Centenarians-A Pathway To Longevity?

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Papers referenced in the video:
The Age-Accompanied and Diet-Associated Remodeling of the Phospholipid, Amino Acid, and SCFA Metabolism of Healthy Centenarians from a Chinese Longevous Region: A Window into Exceptional Longevity
https://pubmed.ncbi.nlm.nih.gov/36297104/

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
https://pubmed.ncbi.nlm.nih.gov/32082260/

Quantifying Biological Age: Blood Test #6 in 2022

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The Excel file to calculate Levine’s Biological Age is embedded in this link from my website:
https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

The Cholesterol-DHEA-S Experiment; A Role For Thyroid Function on DHEA-S And/Or Homocysteine?

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Papers referenced in the video:
Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives
https://pubmed.ncbi.nlm.nih.gov/31201927/

Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow up study in a community based cohort (Tanushimaru study)
https://pubmed.ncbi.nlm.nih.gov/18422949/

Alteration of serum dehydroepiandrosterone and its sulfated derivative in hypothyroidism
https://www.ipinnovative.com/journals/IJCBR/article-full-text/7778

Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism
https://pubmed.ncbi.nlm.nih.gov/11523906/

Serum Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate, and Pregnenolone Sulfate Concentrations in Patients with Hyperthyroidism and Hypothyroidism
https://pubmed.ncbi.nlm.nih.gov/10759476/

Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism
https://pubmed.ncbi.nlm.nih.gov/10475887/

Improve Lung Function, Reduce Blood Pressure, Slow Brain Aging?

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Papers referenced in the video:
Biological aging of human body and brain systems (preprint)
https://www.medrxiv.org/content/10.1101/2022.09.03.22279337v1.full.pdf

A Physiology Clock for Human Aging (preprint)
https://www.biorxiv.org/content/10.1101/2022.04.14.488358v1.full

Spirometry Reference Equations for Central European Populations from School Age to Old Age https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052619

An Integrated, Multimodal, Digital Health Solution for Chronic Obstructive Pulmonary Disease: Prospective Observational Pilot Study
https://pubmed.ncbi.nlm.nih.gov/35142291/

Influence of Inspiratory Muscle Training of Various Intensities on the Physical Performance of Long-Distance Runners
https://pubmed.ncbi.nlm.nih.gov/33312301/

Time-efficient, high-resistance inspiratory muscle strength training for
cardiovascular aging
https://pubmed.ncbi.nlm.nih.gov/34389471/

Optimal Blood Pressure Keeps Our Brains Younger
https://pubmed.ncbi.nlm.nih.gov/34675795/

Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716867/

Resting Heart Rate And Heart Rate Variability: What’s Optimal, 1,502 Days of Data

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Papers referenced in the video:
Biological aging of human body and brain systems
https://www.medrxiv.org/content/10.1101/2022.09.03.22279337v1

Relation of high heart rate variability to healthy longevity
https://pubmed.ncbi.nlm.nih.gov/20381674/

Heart Rate Variability and Exceptional Longevity
https://pubmed.ncbi.nlm.nih.gov/33041862/

Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults
https://pubmed.ncbi.nlm.nih.gov/32023264/

Heart rate variability with photoplethysmography in 8 million individuals: a cross-sectional study
https://pubmed.ncbi.nlm.nih.gov/33328029/

DHEA-S Is A Weakness In My Data: Blood Test #5 in 2022

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Papers referenced in the video:
Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults
https://pubmed.ncbi.nlm.nih.gov/30733566/

The Value of Serum Albumin and High-Density Lipoprotein Cholesterol in Defining Mortality Risk in Older Persons with Low Serum Cholesterol
https://pubmed.ncbi.nlm.nih.gov/11559371/

Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives
https://pubmed.ncbi.nlm.nih.gov/31201927/

Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas
https://pubmed.ncbi.nlm.nih.gov/32751564/

Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow up study in a community based cohort (Tanushimaru study)
https://pubmed.ncbi.nlm.nih.gov/18422949/

Quantifying Biological Age: Blood Test #5 in 2022

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Papers referenced in the video:
A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study
https://pubmed.ncbi.nlm.nih.gov/30596641/

Underlying features of epigenetic aging clocks in vivo and in vitro
https://pubmed.ncbi.nlm.nih.gov/32930491/

Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants
https://pubmed.ncbi.nlm.nih.gov/33684206/

Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations
https://pubmed.ncbi.nlm.nih.gov/29340580/

The Excel file to calculate Levine’s Biological Age is embedded in this link from my website:
https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

Epigenetic Tests #1 and 2: Horvath, Hannum, DunedinPACE

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Papers referenced in the video:
Underlying features of epigenetic aging clocks in vivo and in vitro
https://pubmed.ncbi.nlm.nih.gov/32930491/

DNA methylation‐based measures of biological age: meta‐analysis predicting time to death
https://pubmed.ncbi.nlm.nih.gov/27690265/

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
https://pubmed.ncbi.nlm.nih.gov/26678252/

DunedinPACE, a DNA methylation biomarker of the pace of aging
https://pubmed.ncbi.nlm.nih.gov/35029144/

Effect of Long-Term Caloric Restriction on DNA Methylation Measures of BiologicalAging in Healthy Adults: CALERIE™ Trial Analysis
https://www.medrxiv.org/content/10.1101/2021.09.21.21263912v1.full.pdf

Glycine + N-Acetyl Cysteine Supplementation Increases Lifespan

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Paper referenced in the video:
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/35975308/

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in
Mice Increases Length of Life by Correcting Glutathione
Deficiency, Oxidative Stress, Mitochondrial Dysfunction,
Abnormalities in Mitophagy and Nutrient Sensing,
and Genomic Damage
https://pubmed.ncbi.nlm.nih.gov/35268089/

Glycine and N-acetylcysteine (GlyNAC) supplementation in
older adults improves glutathione deficiency, oxidative
stress, mitochondrial dysfunction, inflammation, insulin
resistance, endothelial dysfunction, genotoxicity, muscle
strength, and cognition: Results of a pilot clinical trial
https://pubmed.ncbi.nlm.nih.gov/33783984/