Measurement of biological age with Levine’s Phenotypic Age calculator is strongly correlated with chronological age (r=0.94; see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). In 2019, I measured all 9 of its analytes 3 times, with biological age readings of 35.39y, 35.58y, and 31.3y, for an average 2019 biological age of 34.09y (see https://michaellustgarten.com/2019/11/01/biological-age-31-3y-chronological-age-46y/). That’s 12 […]
Biological Age
The reference range for uric acid is 4.0 – 8 mg/dL for men, and 2.5 – 7 mg/dL for women. Are these values optimal for health? To answer that question, let’s have a look at how circulating levels of uric acid change during aging, and their association with risk of […]
Besides diet (https://michaellustgarten.com/2019/12/07/slowing-epigenetic-aging-with-diet/), are there other factors that may impact epigenetic aging? First, let’s have a look at clinically relevant variables, including inflammation, the lipid profile, kidney function, blood pressure, and body size/dimensions (Liu et al. 2019): One of the strongest correlations for the clinical variables with epigenetic aging (AgeAccelGrim) […]
To make it easier to review the aging and all-cause mortality data for the circulating biomarkers that are contained within the biological age calculator, Phenotypic Age (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/), here’s a checklist! 1. Albumin: https://michaellustgarten.com/2019/09/22/optimizing-serum-levels-of-albumin-data-from-20-blood-tests/ 2. Creatinine: https://michaellustgarten.com/2019/11/18/optimizing-biologic-age-creatinine/ 3. Glucose: https://michaellustgarten.com/2019/10/04/blood-glucose-whats-optimal/ 4. C-reactive protein: https://michaellustgarten.com/2019/10/19/optimizing-biological-age-crp/ 5. Lymphocyte %: https://michaellustgarten.com/2019/11/16/lympho-mortal/ 6. Mean […]
My average biological age in 2019 is 12 years younger than my chronological age (46y) based on the Phenotypic Age calculator (https://michaellustgarten.com/2019/11/01/biological-age-31-3y-chronological-age-46y/), and 16y younger based on aging.ai (https://michaellustgarten.com/2019/11/04/years-of-biological-aging-in-the-past-4-years/). One factor that likely contributes to my relatively youthful biological age is my diet. Shown below is my average daily dietary […]
In an earlier post (https://michaellustgarten.com/2018/06/26/maximizing-health-and-lifespan-is-calorie-restriction-essential/), I documented my aging.ai biologic age for 13 blood test measurements from 2016 – 2019. If you missed that post, here are those data: Note that note my average biologic age has slowly increased from 2016 to 2019, from 28y in 2016 (2 measurements), to […]
On June 10, 2019 (for the first time) I measured all of the blood test variables that are included in the biologic age calculator, Phenotypic Age, and ended up with a biological age = 35.39y (https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). While that value is 23% younger than my chronological age (46y), I knew that […]
Circulating levels of white blood cells (WBCs) are one of the 10 variables used to quantify biological age with PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age). The reference range for WBCs is 4.5 – 11 *10^9 cells/L, but within that range, what’s optimal? Several studies have reported that WBCs greater than 5 are associated with an […]
Alkaline phosphatase (ALP) is one of the 10 variables used to quantify biological age with PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age). The reference range for alkaline phosphatase is 20 – 140 IU/L*, but within that range, what’s optimal? Two separate meta-analyses have investigated the association between serum levels of ALP with risk of death […]
The reference range for circulating levels of glucose is 70-130 mg/dL. That’s a wide range, so what’s optimal, especially considering that glucose is one of the variables used to quantify of biological age (https://michaellustgarten.com/2019/09/09/quantifying-biological-age)? In the largest study published for this subject (12,455,361 adults), risk of death for all causes […]
Can biological age be optimized? The red blood cell (RBC) distribution width (RDW%) is one of the variables included in the PhenoAge biological age calculator (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). Although the RDW% reference range is 11.5% – 14.5%, what values are optimal in terms a youthful biological age, and minimized disease risk? […]
In an earlier post, I showed published data that albumin levels decrease with aging, and that lower levels are associated with an increased all-cause mortality risk (https://michaellustgarten.com/2018/07/06/serum-albumin-and-acm/). I also showed my own blood test data (n=11), which included a strong correlation for albumin with my dietary intake of beta-carotene (r = […]
Have a listen, I was on Generation Bold Radio yesterday, 9.14.2019! https://www.generationboldradio.us/
DNAmPhenoAge_gen (1)In an earlier post, I wrote about quantifying my biological age with aging.ai (https://michaellustgarten.com/2018/06/26/maximizing-health-and-lifespan-is-calorie-restriction-essential/). The importance of that post is illustrated by the finding that based on data from 13 blood tests between 2016 – 2019, my average biological age is 29.2y, which is ~33% younger than my chronological […]
My goal is to break the world record for lifespan, 122 years, which is currently held by Jean Calment. How do I plan to do that? A good start would be calorie restriction (CR), a diet where you eat 10-30%+ less calories than your normal intake. CR is the gold […]