Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD Papers referenced in the video: Chocolate consumption and all-cause and cause-specific mortality in a US population: a post hoc analysis of the PLCO cancer screening trial https://pubmed.ncbi.nlm.nih.gov/34329196/ Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in […]

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD Papers referenced in the video: Dietary Intakes of Eggs and Cholesterol in Relation to All-Cause and Heart Disease Mortality: A Prospective Cohort Study https://pubmed.ncbi.nlm.nih.gov/32400247/ Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality https://pubmed.ncbi.nlm.nih.gov/30874756/

Join us on Patreon! https://www.patreon.com/MichaelLustga… Papers referenced in the video: Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older https://pubmed.ncbi.nlm.nih.gov/34585… A defined, plant-based diet utilized in an outpatient cardiovascular clinic effectively treats hypercholesterolemia and hypertension and reduces medications https://pubmed.ncbi.nlm.nih.gov/29575…

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD Levine’s Biological age calculator is embedded as an Excel file in this link: https://michaellustgarten.com/2019/09/09/quantifying-biological-age/ Papers referenced in the video: The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population https://immunityageing.biomedcentral.com/articles/10.1186/s12979-018-0126-7 Commonly used clinical chemistry tests as mortality predictors: Results from two […]

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD Levine’s Biological age calculator is embedded as an Excel file in this link: https://michaellustgarten.com/2019/09/09/quantifying-biological-age/ DNA methylation GrimAge strongly predicts lifespan and healthspan https://pubmed.ncbi.nlm.nih.gov/30669119/ Fisetin is a senotherapeutic that extends health and lifespan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/ Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the […]

For more info, join us on Patreon! https://www.patreon.com/MichaelLustga… Papers referenced in the video: Human microbiome: an academic update on human body site specific surveillance and its possible role https://pubmed.ncbi.nlm.nih.gov/32524… Taxonomic signatures of cause-specific mortality risk in human gut microbiome https://pubmed.ncbi.nlm.nih.gov/33976… The Role of Short-Chain Fatty Acids From Gut Microbiota in […]

Papers referenced in the video: Loss of Life Expectancy by 10 Years or More From Elevated Aspartate Aminotransferase: Finding Aspartate Aminotransferase a Better Mortality Predictor for All-Cause and Liver-Related than Alanine Aminotransferase https://pubmed.ncbi.nlm.nih.gov/31425… Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study https://pubmed.ncbi.nlm.nih.gov/29491…

HOMA calculator: https://www.omnicalculator.com/health… Papers referenced in the video: Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice https://pubmed.ncbi.nlm.nih.gov/24175… Glucose regulation and oxidative stress in healthy centenarians https://pubmed.ncbi.nlm.nih.gov/12543… Distribution of blood glucose and prevalence of diabetes among centenarians and oldest-old in China: based on the China […]

Papers referenced in the video: Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence: https://pubmed.ncbi.nlm.nih.gov/29514… NAD and the aging process: Role in life, death and everything in between: https://pubmed.ncbi.nlm.nih.gov/27825… Flavonoids as inhibitors of human CD38: https://pubmed.ncbi.nlm.nih.gov/21641… Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ […]

Papers referenced in the video: Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130…​ Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels: https://pubmed.ncbi.nlm.nih.gov/27567…​ Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study: https://pubmed.ncbi.nlm.nih.gov/7474221/​ Total plasma homocysteine values among elderly […]

Papers referenced in the video: The Hallmarks of Aging: https://www.ncbi.nlm.nih.gov/pmc/arti…​ Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives: https://www.ncbi.nlm.nih.gov/pmc/arti…​ Telomeres and the natural lifespan limit in humans: https://www.ncbi.nlm.nih.gov/pmc/arti…​ Telomere Length and All-Cause Mortality: A Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/30254…​ Comparability of biological aging measures in the National […]

In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis. In addition, I’ve tested my HDL […]

Papers referenced in the video: DNA methylation GrimAge strongly predicts lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/30669…​ GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality: https://pubmed.ncbi.nlm.nih.gov/33211…​ Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic […]

The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes. Viruses, including SARS-CoV-2 and HSV-1 cause mitochondrial dysfunction-more specifically, they cause mitochondria to release some of their DNA, which triggers antiviral immunity. When considering that blood levels of mitochondrial DNA increase during aging, […]

In an earlier video, I presented data for apigenin’s ability to increase levels of NAD+. In addition to apigenin’s impact on NAD+, apigenin supplementation increases muscle mass, strength, and treadmill running distance in both young and old mice. Video link for NAD+ is increased in response to apigenin: https://youtu.be/5-2YoGctcCk?list=UUT… Paper […]

The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.

A reduced mortality risk and an increased lifespan has been reported for people who have APOE2 alleles, when compared with APOE3 or APOE4, but beyond associations, data for lifespan in APOE-expressing mice was recently reported, evidence that supports a causative role for APOE on longevity.

In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and […]

LPS increases during aging, which may explain the age-related increase for CD38 and decreased NAD+. LPS is decreased on a calorie restricted diet, but what else can reduce it? In this video, I present evidence for intestinal alkaline phosphatase’s (IAP) role on LPS, and posit that interventions that increase IAP […]

Blood urea nitrogen (BUN) is one of the 19 variables found on the biological age calculator, aging.ai. It measures the amount of nitrogen, as contained in urea (i.e., blood urea nitrogen, BUN) in your blood. The reference range for BUN is 5 – 20 mg/dL, but within that range, what’s […]

Consistent exercise training would seem like the obvious choice to reduce resting heart rate (RHR) and to increase heart rate variability (HRV). Are there other factors that can impact these variables? Body weight and daily calorie intake may affect RHR and HRV, and in the video I present 700+ days […]