Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD Papers referenced in the video: Chocolate consumption and all-cause and cause-specific mortality in a US population: a post hoc analysis of the PLCO cancer screening trial https://pubmed.ncbi.nlm.nih.gov/34329196/ Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in […]
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD Papers referenced in the video: Dietary Intakes of Eggs and Cholesterol in Relation to All-Cause and Heart Disease Mortality: A Prospective Cohort Study https://pubmed.ncbi.nlm.nih.gov/32400247/ Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality https://pubmed.ncbi.nlm.nih.gov/30874756/
Join us on Patreon! https://www.patreon.com/MichaelLustga… Papers referenced in the video: Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older https://pubmed.ncbi.nlm.nih.gov/34585… A defined, plant-based diet utilized in an outpatient cardiovascular clinic effectively treats hypercholesterolemia and hypertension and reduces medications https://pubmed.ncbi.nlm.nih.gov/29575…
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD Levine’s Biological age calculator is embedded as an Excel file in this link: https://michaellustgarten.com/2019/09/09/quantifying-biological-age/ Papers referenced in the video: The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population https://immunityageing.biomedcentral.com/articles/10.1186/s12979-018-0126-7 Commonly used clinical chemistry tests as mortality predictors: Results from two […]
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD Levine’s Biological age calculator is embedded as an Excel file in this link: https://michaellustgarten.com/2019/09/09/quantifying-biological-age/ DNA methylation GrimAge strongly predicts lifespan and healthspan https://pubmed.ncbi.nlm.nih.gov/30669119/ Fisetin is a senotherapeutic that extends health and lifespan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/ Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the […]
For more info, join us on Patreon! https://www.patreon.com/MichaelLustga… Papers referenced in the video: Human microbiome: an academic update on human body site specific surveillance and its possible role https://pubmed.ncbi.nlm.nih.gov/32524… Taxonomic signatures of cause-specific mortality risk in human gut microbiome https://pubmed.ncbi.nlm.nih.gov/33976… The Role of Short-Chain Fatty Acids From Gut Microbiota in […]
2021 Update: Can I still do 12 Pull-Ups?
Here’s my latest video! For more info on my data-to-day data for diet, fitness, sneak peaks for videos in production and more, join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD
Join me on Patreon! https://www.patreon.com/MichaelLustga…
Papers referenced in the video: Loss of Life Expectancy by 10 Years or More From Elevated Aspartate Aminotransferase: Finding Aspartate Aminotransferase a Better Mortality Predictor for All-Cause and Liver-Related than Alanine Aminotransferase https://pubmed.ncbi.nlm.nih.gov/31425… Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study https://pubmed.ncbi.nlm.nih.gov/29491…
HOMA calculator: https://www.omnicalculator.com/health… Papers referenced in the video: Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice https://pubmed.ncbi.nlm.nih.gov/24175… Glucose regulation and oxidative stress in healthy centenarians https://pubmed.ncbi.nlm.nih.gov/12543… Distribution of blood glucose and prevalence of diabetes among centenarians and oldest-old in China: based on the China […]
For those who track their diet, eating only the RDA for many nutrients may not optimize health. For example, the RDA for selenium is 55 micrograms per day, but is that amount optimal for reducing risk of death for all causes?
Papers referenced in the video: Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence: https://pubmed.ncbi.nlm.nih.gov/29514… NAD and the aging process: Role in life, death and everything in between: https://pubmed.ncbi.nlm.nih.gov/27825… Flavonoids as inhibitors of human CD38: https://pubmed.ncbi.nlm.nih.gov/21641… Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ […]
Papers referenced in the video: Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130… Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels: https://pubmed.ncbi.nlm.nih.gov/27567… Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study: https://pubmed.ncbi.nlm.nih.gov/7474221/ Total plasma homocysteine values among elderly […]
Paper references for Levine’s Phenotypic Age calculator and aging.ai: An epigenetic biomarker of aging for lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/29676… Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations: https://pubmed.ncbi.nlm.nih.gov/29340…
Papers referenced in the video: The Hallmarks of Aging: https://www.ncbi.nlm.nih.gov/pmc/arti… Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives: https://www.ncbi.nlm.nih.gov/pmc/arti… Telomeres and the natural lifespan limit in humans: https://www.ncbi.nlm.nih.gov/pmc/arti… Telomere Length and All-Cause Mortality: A Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/30254… Comparability of biological aging measures in the National […]
In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis. In addition, I’ve tested my HDL […]
Papers referenced in the video: DNA methylation GrimAge strongly predicts lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/30669… GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality: https://pubmed.ncbi.nlm.nih.gov/33211… Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic […]
Discussed in the video: Data for changes in kidney function during aging, kidney function values that are associated with an increased risk of death for all causes What’s my data for kidney function, 2006 – 2020? Can diet impact kidney function? Within my data, which foods are correlated with good […]
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes. Viruses, including SARS-CoV-2 and HSV-1 cause mitochondrial dysfunction-more specifically, they cause mitochondria to release some of their DNA, which triggers antiviral immunity. When considering that blood levels of mitochondrial DNA increase during aging, […]
The maximal reduction for biological age when using the biological age calculator, Phenotypic Age, is ~20 years. In other words, if I’m 80 years old and my biomarkers are all reflective of youth, the lowest possible biological age will be ~60 years old. One reason for that is the inclusion […]
In an earlier video, I presented data for apigenin’s ability to increase levels of NAD+. In addition to apigenin’s impact on NAD+, apigenin supplementation increases muscle mass, strength, and treadmill running distance in both young and old mice. Video link for NAD+ is increased in response to apigenin: https://youtu.be/5-2YoGctcCk?list=UUT… Paper […]
Here’s the first interview clip (of a series) with Modern Healthspan on YouTube where we discuss the role of the microbiome on health and longevity: Part II: Skin, Oral Microbiome & Immune System Part III: Optimal Health with Soluble Fiber Part IV – Microbial Burden & Hallmarks of Aging Part […]
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.
LDL is arguably the most debated biomarker in terms of what’s optimal for health. In the video, I present data showing that 100 – 140, not 50 – 70 mg/dL may be optimal in terms of minimizing disease risk and maximizing longevity.
White blood cells (WBCs) comprise many different cell types, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Neutrophils, lymphocytes, and monocytes account for ~99% of WBCs, and accordingly, in the video I propose optimal ranges for these cell types in terms of health and longevity.
In the video below, Steve Hill from Lifespan.io and I talk about findings from a recent paper (https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200306) that supports a role for the gut microbiome on Alxheimer’s disease. Check it out!
Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 – 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video, I present data for 85y – 115yr olds that additionally suggests HDL in the 55 – 60 mg/dL range […]
Animal products, including meat, cheese, and eggs contain carnitine and choline, metabolites that are converted by gut bacteria into TMA, which is then converted by the liver into TMAO. Plasma levels of TMAO are associated with an increased risk of disease and death, so should we limit intake of these […]
A reduced mortality risk and an increased lifespan has been reported for people who have APOE2 alleles, when compared with APOE3 or APOE4, but beyond associations, data for lifespan in APOE-expressing mice was recently reported, evidence that supports a causative role for APOE on longevity.
My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them with diet going forward.
After going on Joe Rogan’s podcast, Paul Saladino, MD, posted his show notes, which included his blood test results. Based on that data, is his biological age optimal while on a carnivore diet?
Sleep changes during aging may impact Alzheimer’s disease risk, and with the goal of minimizing that risk, can sleep, in particular, levels of deep sleep, be optimized?
11 epigenetic clocks have been published since 2011, but which is best for predicting aging and age-related disease? In this video, I present findings from a recent publication, “Underlying features of epigenetic aging clocks in vitro and in vivo”, that compared data for 11 epigenetic clocks, and derived a new […]
Here’s a podcast that was recorded with WildHealth, enjoy!
Cooking foods at temperatures higher than boiling produces advanced glycation end (AGE) products, which induce insulin resistance and inflammation, and shorten lifespan in mice. Similar data exists in humans for the effect of dietary AGE products on insulin resistance and inflammation, and a higher dietary AGE product intake is associated […]
Maximal lifespan in calorie restricted (CR) mice can range from 45 – 55 months. In this video, I present data for 3 studies on rapamycin-can it beat CR for maximal lifespan?
On my latest blood test (August 2015), my total cholesterol was 127 mg/dL-is that value optimal for health and longevity? Based on data for 1,104,294 men younger than 60y (median age, 40y) that were followed for up to 14 years (Fulks et al. 2009), my 127 mg/dL value (1 – 2.4%) […]
In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and […]
LPS increases during aging, which may explain the age-related increase for CD38 and decreased NAD+. LPS is decreased on a calorie restricted diet, but what else can reduce it? In this video, I present evidence for intestinal alkaline phosphatase’s (IAP) role on LPS, and posit that interventions that increase IAP […]
My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them going forward.
Blood urea nitrogen (BUN) is one of the 19 variables found on the biological age calculator, aging.ai. It measures the amount of nitrogen, as contained in urea (i.e., blood urea nitrogen, BUN) in your blood. The reference range for BUN is 5 – 20 mg/dL, but within that range, what’s […]
Consistent exercise training would seem like the obvious choice to reduce resting heart rate (RHR) and to increase heart rate variability (HRV). Are there other factors that can impact these variables? Body weight and daily calorie intake may affect RHR and HRV, and in the video I present 700+ days […]