Blood Test Analysis: 100 – 111y (Centenarians, Semi- and Super-Centenarians)
In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and super-centenarians (110y+).
Amazing work you are doing! Thank you!
Excellent your remark on albumin as underrated biomarkers, mostly as you can act on it with diet. Interesting the albumin convergence between males and female at 75 yo. Any clue why so?
I guess, when on creatinine, it would be good to also check kidney function looking at eGFR (it includes in particular the age correction). Could this helps in disentangling the impact of muscle mass loss? While I am on this, please note the values of eGFR might changes significantly according to the hydration status the day before and at the moment of the blood draw.
Very interesting the points on inflammation. I wonder how to disentangle the age impact from the underlying conditions such as recurrent infections which might be running in the elderly. I expect this would impact trends in longitudinal studies. Related is the excellent point you make on CMV and immunosenescence!
Please keep up with the good work!
Thanks Albedo. I hadn’t considered the albumin data in the 70yr old groups, but upon further inspection, it’s not surprising when looking at the albumin aging data, where there’s also a convergence for men and women in their 70s.
Ha, yes, you meant “creatine”, not creatinine, and I agree. It’s doubtful many older adults are taking that supplement, so that’s probably not the explanation. I also agree about hydration, but note that these data are in thousands of subjects. If hydration was a rampant issue, you’d expect to affect the creatinine results of a small sample sized study, but less so in a very large study.
Also, I’d argue that the age-related increase for inflammation is in large part caused by microbial products or more microbes in the blood. Beyond LPS, some of that will be addressed in my next video…
Sorry Michael for my poor English … I mislead you. I meant “creatinine” and not creatine and by “when on creatinine” I meant “when considering creatinine” not supplementing with it 🙂 I agree with the point you make on the study size! I typically record my drinking before doing this test and noticed differences (e.g. if I drink more my eGFR increases). I also test for Cystatin C more recently as a more sensitive marker for kidneys.
Very important the point on microbial products and LPS, waiting for your next video!