Glutathione Restoration Improves Hallmarks Of Aging in Older Adults

Papers referenced int the video:

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation: https://pubmed.ncbi.nlm.nih.gov/21795…​

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial: https://pubmed.ncbi.nlm.nih.gov/33783…

Glutathione declines during aging (Age-related changes in the glutathione redox system): https://pubmed.ncbi.nlm.nih.gov/11835…

2 thoughts on “Glutathione Restoration Improves Hallmarks Of Aging in Older Adults

  1. Ole

    9,3 grams of NAC seems like a lot. Also NAC has pro-oxidant effects at high doses. Considering that a dosage above 1,2 grams pr. day can cause headache, nausea, abdominal pain, vomiting, constipation, and diarrhea, 9.3 seems way too much. There must be safer ways to raise glutathione.

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    1. Michael Lustgarten Post author

      That’s a fair point, and also, it’s unknown how the longer-term effects (>25 weeks) of those doses would impact health. But, if those doses were bad for health in the shorter-term, one would expect worse biomarkers, but in fact, the opposite was true.

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