Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation: https://pubmed.ncbi.nlm.nih.gov/21795…
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial: https://pubmed.ncbi.nlm.nih.gov/33783…
Ph.D, Physiology, University of Texas Health Science Center at San Antonio, 2009
B.S., Biochemistry, Queens College, 2003
B.A, English Textual Studies, 1994, Syracuse University
2 thoughts on “Glutathione Restoration Improves Hallmarks Of Aging in Older Adults”
9,3 grams of NAC seems like a lot. Also NAC has pro-oxidant effects at high doses. Considering that a dosage above 1,2 grams pr. day can cause headache, nausea, abdominal pain, vomiting, constipation, and diarrhea, 9.3 seems way too much. There must be safer ways to raise glutathione.
That’s a fair point, and also, it’s unknown how the longer-term effects (>25 weeks) of those doses would impact health. But, if those doses were bad for health in the shorter-term, one would expect worse biomarkers, but in fact, the opposite was true.
Papers referenced in the video: Dietary Thiols: A Potential Supporting Strategy against Oxidative Stress in Heart Failure and Muscular Damage during Sports Activity: https://www.ncbi.nlm.nih.gov/pmc/arti… Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? https://pubmed.ncbi.nlm.nih.gov/27444… Is ergothioneine a ‘longevity vitamin’ limited […]
9,3 grams of NAC seems like a lot. Also NAC has pro-oxidant effects at high doses. Considering that a dosage above 1,2 grams pr. day can cause headache, nausea, abdominal pain, vomiting, constipation, and diarrhea, 9.3 seems way too much. There must be safer ways to raise glutathione.
That’s a fair point, and also, it’s unknown how the longer-term effects (>25 weeks) of those doses would impact health. But, if those doses were bad for health in the shorter-term, one would expect worse biomarkers, but in fact, the opposite was true.