Papers referenced int the video:
Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation: https://pubmed.ncbi.nlm.nih.gov/21795…
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial: https://pubmed.ncbi.nlm.nih.gov/33783…
Glutathione declines during aging (Age-related changes in the glutathione redox system): https://pubmed.ncbi.nlm.nih.gov/11835…
9,3 grams of NAC seems like a lot. Also NAC has pro-oxidant effects at high doses. Considering that a dosage above 1,2 grams pr. day can cause headache, nausea, abdominal pain, vomiting, constipation, and diarrhea, 9.3 seems way too much. There must be safer ways to raise glutathione.
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That’s a fair point, and also, it’s unknown how the longer-term effects (>25 weeks) of those doses would impact health. But, if those doses were bad for health in the shorter-term, one would expect worse biomarkers, but in fact, the opposite was true.
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