Glutathione Restoration Improves Hallmarks Of Aging in Older Adults

Papers referenced int the video:

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation: https://pubmed.ncbi.nlm.nih.gov/21795…​

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial: https://pubmed.ncbi.nlm.nih.gov/33783…

Glutathione declines during aging (Age-related changes in the glutathione redox system): https://pubmed.ncbi.nlm.nih.gov/11835…

Michael Lustgarten

Ph.D, Physiology, University of Texas Health Science Center at San Antonio, 2009 B.S., Biochemistry, Queens College, 2003 B.A, English Textual Studies, 1994, Syracuse University

2 thoughts on “Glutathione Restoration Improves Hallmarks Of Aging in Older Adults

  1. 9,3 grams of NAC seems like a lot. Also NAC has pro-oxidant effects at high doses. Considering that a dosage above 1,2 grams pr. day can cause headache, nausea, abdominal pain, vomiting, constipation, and diarrhea, 9.3 seems way too much. There must be safer ways to raise glutathione.

    1. That’s a fair point, and also, it’s unknown how the longer-term effects (>25 weeks) of those doses would impact health. But, if those doses were bad for health in the shorter-term, one would expect worse biomarkers, but in fact, the opposite was true.

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