Tag Archives: Mitochondrial function

Glutathione Restoration Improves Hallmarks Of Aging in Older Adults

Papers referenced int the video:

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation: https://pubmed.ncbi.nlm.nih.gov/21795…​

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial: https://pubmed.ncbi.nlm.nih.gov/33783…

Glutathione declines during aging (Age-related changes in the glutathione redox system): https://pubmed.ncbi.nlm.nih.gov/11835…

Microbial Products Affect the Hallmarks Of Aging: 1) Mitochondrial Function

The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.