Tag Archives: Cronometer

Methionine Restriction Extends Lifespan: Roles For SCFAs And FGF21, But Not Calorie Restriction

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Papers referenced in the video:
Dietary Methionine via Dose-Dependent Inhibition of Short-Chain Fatty Acid Production Capacity Contributed to a Potential Risk of Cognitive Dysfunction in Mice
https://pubmed.ncbi.nlm.nih.gov/36413479/

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age
https://pubmed.ncbi.nlm.nih.gov/19414512/

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice
https://pubmed.ncbi.nlm.nih.gov/31195972/

Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
https://pubmed.ncbi.nlm.nih.gov/15924568/

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
https://pubmed.ncbi.nlm.nih.gov/24245565/

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
https://pubmed.ncbi.nlm.nih.gov/23066506/

What I eat: Giant Salad!

Another meal that I eat 1-2x per week is a giant (delicious!) salad.

salad2

What’s in it? Approximately 1 pound of romaine lettuce, 1 pint of cherry tomates, 6-8 ounces of purple cabbage, ~3 ounces of pickles, and occasionally, 2-4 ounces of corn.  To top it off, I make a spicy-sesame dressing that includes 1 jalapeno, ~1 ounce of lemon juice, ~1 ounce of sesame seeds, 2-4 grams of ground cumin seed, ~10 grams of raw garlic, and 4-6 oz. of water. I then blend the dressing ingredients and add it to the salad!

salad ingred

How about nutrition? For 528 calories, it’s a nutritional All-Star for many things, including protein, fiber, calcium, magnesium, zinc, and many other nutritents.

salad nutrition

7/2017 Update: To increase my folate intake from my usual 1200 mcg to ~1500 mcg/day, I’ve increased the romaine lettuce component of the salad to ~20 oz. Also, I’ve added a small habanero in addition to the jalapeno/fresno pepper for more spice. Still yum!

If you’re interested, please have a look at my book!