Tag Archives: calorie restriction

Epigenetic Tests #1 and 2: Horvath, Hannum, DunedinPACE

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TruDiagnostic Discount Link (Epigenetic Testing)
CONQUERAGING!
https://bit.ly/3Rken0n

Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Cronometer Discount Link (Daily diet tracking):
https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

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Papers referenced in the video:
Underlying features of epigenetic aging clocks in vivo and in vitro
https://pubmed.ncbi.nlm.nih.gov/32930491/

DNA methylation‐based measures of biological age: meta‐analysis predicting time to death
https://pubmed.ncbi.nlm.nih.gov/27690265/

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
https://pubmed.ncbi.nlm.nih.gov/26678252/

DunedinPACE, a DNA methylation biomarker of the pace of aging
https://pubmed.ncbi.nlm.nih.gov/35029144/

Effect of Long-Term Caloric Restriction on DNA Methylation Measures of BiologicalAging in Healthy Adults: CALERIE™ Trial Analysis
https://www.medrxiv.org/content/10.1101/2021.09.21.21263912v1.full.pdf

Fasting Without Calorie Restriction Extends Lifespan

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Join us on Patreon!
https://www.patreon.com/MichaelLustgartenPhD

Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Cronometer Discount Link (Daily diet tracking):
https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

Support the channel with Buy Me A Coffee!
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Paper referenced in the video:
Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories
https://pubmed.ncbi.nlm.nih.gov/30197301/

Lifespan Extension With Calorie Restriction, Fasting, And Circadian Alignment

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Join us on Patreon!
https://www.patreon.com/MichaelLustgartenPhD

Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Cronometer Discount Link (Daily diet tracking):
https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

You can support the channel by buying me a coffee!
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Papers referenced in the video:
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice
https://www.nature.com/articles/s42255-021-00466-9

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
https://pubmed.ncbi.nlm.nih.gov/35511946/

Fasting Drives The Geroprotective Effects Of A Calorie-Restricted Diet

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Paper referenced in the video:

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice https://www.nature.com/articles/s42255-021-00466-9

Insulin Sensitivity Is A Hallmark Of Longevity

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HOMA calculator: https://www.omnicalculator.com/health…

Papers referenced in the video:

Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice https://pubmed.ncbi.nlm.nih.gov/24175…

Glucose regulation and oxidative stress in healthy centenarians https://pubmed.ncbi.nlm.nih.gov/12543…

Distribution of blood glucose and prevalence of diabetes among centenarians and oldest-old in China: based on the China Hainan Centenarian Cohort Study and China Hainan Oldest-old Cohort Study https://pubmed.ncbi.nlm.nih.gov/32643…

Prevalence and Ethnic Pattern of Diabetes and Prediabetesin China in 2013 https://pubmed.ncbi.nlm.nih.gov/28655…

Families enriched for exceptional longevity also have increased health-span: findings from the long life family study https://pubmed.ncbi.nlm.nih.gov/24350…

SIRT6 Positively Affects The Hallmarks Of Aging And Extends Lifespan

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Papers referenced in the video:

Sirtuins, Healthspan, and Longevity in Mammals https://www.sciencedirect.com/science…

Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH https://pubmed.ncbi.nlm.nih.gov/24011…

Resveratrol improves health and survival of mice on a high-calorie diet https://pubmed.ncbi.nlm.nih.gov/17086…

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice https://pubmed.ncbi.nlm.nih.gov/20974…

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer https://www.nature.com/articles/ncomm…

Restoration of energy homeostasis by SIRT6 extends healthy lifespan https://pubmed.ncbi.nlm.nih.gov/34050…

The sirtuin SIRT6 regulates lifespan in male mice https://pubmed.ncbi.nlm.nih.gov/22367…

SIRT6 in Senescence and Aging-Related Cardiovascular Diseases https://pubmed.ncbi.nlm.nih.gov/33855…

Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling https://pubmed.ncbi.nlm.nih.gov/26940…

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6 https://pubmed.ncbi.nlm.nih.gov/27101…

A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes https://pubmed.ncbi.nlm.nih.gov/33920…

Acute Exercise Leads to Regulation of Telomere Associated Genes and MicroR A Expression in Immune Cells https://pubmed.ncbi.nlm.nih.gov/24752…

The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men https://pubmed.ncbi.nlm.nih.gov/32919…

High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?

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Papers referenced in the video:

FGF21 and Chronic Kidney Disease: https://www.sciencedirect.com/science…

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21: https://pubmed.ncbi.nlm.nih.gov/18585…

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877…

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression: https://pubmed.ncbi.nlm.nih.gov/31773…

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses: https://pubmed.ncbi.nlm.nih.gov/28552…

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging: https://pubmed.ncbi.nlm.nih.gov/33131…

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue: https://pubmed.ncbi.nlm.nih.gov/30043…

Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals: https://pubmed.ncbi.nlm.nih.gov/26042…

Lower All-Cause, Cardiovascular, and Cancer Mortality in Centenarians’ Offspring: https://pubmed.ncbi.nlm.nih.gov/15571…

Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study: https://pubmed.ncbi.nlm.nih.gov/20398…

Blood Test #6 In 2020: What’s My Biological Age?

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Discussed in the video:

What’s my biological age on blood test #6 in 2020?

What’s my average biological age for 2020, and how does it compare with 2019?

Are there links between calorie intake, cardiovascular fitness (RHR, HRV), and diet composition with my biological age?

CD38 Gets In The Way Of NR And NMN For Increasing NAD+

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NR and NMN are popular ways to try to boost levels of NAD+, but that approach hasn’t worked every time in human studies. One reason for that may involve CD38, which degrades both NR and NMN. With the goal of boosting NAD+ levels during aging, why does CD38 increase with age, and what can be done about it? All that and more in this video!