Thyroid Hormones (FT4, FT3): What’s Optimal?

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Papers referenced in the video:
The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective https://pubmed.ncbi.nlm.nih.gov/31074798/

Thyroid hormones and frailty in persons experiencing extreme longevity https://pubmed.ncbi.nlm.nih.gov/32525032/

FT3/FT4 ratio is correlated with all-cause mortality, cardiovascular mortality, and cardiovascular disease risk: NHANES 2007-2012
https://pubmed.ncbi.nlm.nih.gov/36060933/

Relationship of gender and age on thyroid hormone parameters in a large Chinese population https://pubmed.ncbi.nlm.nih.gov/31576967/

Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality https://pubmed.ncbi.nlm.nih.gov/30165411/

Thyroid hormones and frailty in persons experiencing extreme longevity https://pubmed.ncbi.nlm.nih.gov/32525032/

Association of sensitivity to thyroid hormones with all-cause mortality in euthyroid US adults: a nationwide cohort study. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10895331/

2 thoughts on “Thyroid Hormones (FT4, FT3): What’s Optimal?”

  1. Ekil

    i commented on this yt video suggesting that u make a video on body temperature as a biomarker for ageing. im posting my reply here because yt filters comments and for some reason my reply was caught in the filter .

    heating the hypothalamus tricks it into downregulateing body temperature by less than half a degree led to extension of median lifespan by 12-20% in mice .
    https://pubmed.ncbi.nlm.nih.gov/17082459/

    this study shows that an ambient temp of 32.5 degrees (vs 21 degrees) leads to decreased energy expenditure and higher body temperature . somehow 32.5 degrees + fan-generated wind lowered body temperature without affecting energy expenditure , which made lifespan equal to the group with an ambient temp of 21 degrees . so it was lower body temperature which is pro-longevity .
    https://www.nature.com/articles/s42255-022-00545-5

    i can send u either of these articles

    and yes , CR has been shown to lower body temperature in humans and rhesus monkeys

    https://www.semanticscholar.org/reader/f92468763355135bb642ea1ca9b02f8204d38554

    https://www.pnas.org/doi/abs/10.1073/pnas.93.9.4159

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