Papers referenced in the video: Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130… Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels: https://pubmed.ncbi.nlm.nih.gov/27567… Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study: https://pubmed.ncbi.nlm.nih.gov/7474221/ Total plasma homocysteine values among elderly […]
Biohacking
Paper references for Levine’s Phenotypic Age calculator and aging.ai: An epigenetic biomarker of aging for lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/29676… Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations: https://pubmed.ncbi.nlm.nih.gov/29340…
In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis. In addition, I’ve tested my HDL […]
Results for my first blood test in 2021 are in-what’s my biological age, and how am I optimizing it? If you’re interested in calculating your biological age, the spreadsheet is included as an Excel file in this link:
Red blood cells (RBC) are the most abundant cell type in the human body. I’ve tracked my RBC levels in conjunction with diet since 2015, and with the goal of reversing the age-related decline for RBCs, which dietary components have the strongest correlation with RBCs? https://www.youtube.com/watch?v=3JpyDiNxNeE&feature=youtu.be
Discussed in the video: Data for changes in kidney function during aging, kidney function values that are associated with an increased risk of death for all causes What’s my data for kidney function, 2006 – 2020? Can diet impact kidney function? Within my data, which foods are correlated with good […]
Discussed in the video: What’s my biological age on blood test #6 in 2020? What’s my average biological age for 2020, and how does it compare with 2019? Are there links between calorie intake, cardiovascular fitness (RHR, HRV), and diet composition with my biological age?
LDL is arguably the most debated biomarker in terms of what’s optimal for health. In the video, I present data showing that 100 – 140, not 50 – 70 mg/dL may be optimal in terms of minimizing disease risk and maximizing longevity.
White blood cells (WBCs) comprise many different cell types, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Neutrophils, lymphocytes, and monocytes account for ~99% of WBCs, and accordingly, in the video I propose optimal ranges for these cell types in terms of health and longevity.
Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 – 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video, I present data for 85y – 115yr olds that additionally suggests HDL in the 55 – 60 mg/dL range […]
My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them with diet going forward.
Sleep changes during aging may impact Alzheimer’s disease risk, and with the goal of minimizing that risk, can sleep, in particular, levels of deep sleep, be optimized?
Here’s a podcast that was recorded with WildHealth, enjoy!
My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them going forward.
Consistent exercise training would seem like the obvious choice to reduce resting heart rate (RHR) and to increase heart rate variability (HRV). Are there other factors that can impact these variables? Body weight and daily calorie intake may affect RHR and HRV, and in the video I present 700+ days […]
To determine what’s optimal for resting heart rate and heart rate variability, I review the published literature for how they change during aging, and what’s associated with mortality risk. Also included are my data over the past ~2 years, to see how I compare against the literature.
In an earlier video, I presented data for total cholesterol (TC) levels in blood in terms of changes during aging and all-cause mortality risk. I’ve measured TC 25 times in the past 5 years, and in this video, I present that data, and my approach to optimize it. https://www.youtube.com/watch?v=PBv_hXwUqHM&feature=emb_logo
An adequate daily intake of Vitamin K1 is 120 and 90 micrograms/day for males and females, respectively, but are those amounts optimal for health? In this video, I present evidence that consuming more than 1000 micrograms of Vitamin K1/day may be optimal.
In this video, I discuss data for 6 blood test measurements since 2018 that show a Phenotypic (Biological) Age that is ~14 years than my current age (47y). https://youtu.be/85t8vmIgR6s
- Blood Testing
- Blood urea nitrogen
- BMI and all-cause mortality
- C-Reactive Protein
- Creatinine
- Diet and Mortality
- Dietary Fiber
- Dietary Tracking
- Glucose
- Inflammation
- Kidney function
- Lymphocytes
- Mean Corpuscular Volume (MCV)
- Neutrophil/Lymphocyte Ratio
- Presentations
- quantified self
- RDW%
- Uric Acid
- Video
- White Blood Cells
What are the blood biomarkers of a centenarian, and is there room for improvement? Find out in the video below! https://www.youtube.com/watch?v=XhCUuxhxmpg
Here’s a video clip about my latest Biological Age measurement!
Most often overlooked on a standard blood test are the mean corpuscular volume (MCW) and Red Blood Cell Distribution Width (RDW). How do they change during aging, and what’s associated with all-cause mortality risk? Also, with the goal of optimizing MCV and RDW, how does my diet correlate with these […]
In this relatively short clip, I talk about how serum levels of creatinine change during aging, what levels are associated with risk of death for all causes, and I show my own data for 15+ years! https://www.youtube.com/watch?v=PK6oBMMasFU
Interestingly, we recorded this as I was recovering from a respiratory infection. Was it SARS-CoV-2, or influenza? I’ll know later this week! https://www.bisu.bio/biohacking-to-100-longevity-lessons-from-15-years-of-self-tracking-ft-michael-lustgarten-phd/
Here’s a link to a recent interview, https://biohackstack.com/posts/michael-lustgarten/?fbclid=IwAR059Jf6eT4SyvsqTxHaSir2hQuXKjV5R6kLg-7Df1Kc4c7ZKM6Tw-0qRwY Including: How (and why) did you get involved in research in aging and the human microbiome? How did you get started in health optimization / quantified-self? What are your thoughts on biological age testing? Which tests (epigenetic, blood biomarkers, telomere, etc) and […]
Levels of serum albumin peak at about 20 years old (~4.6 g/dL for males, ~4.4 g/dL for females), then decrease during aging, as shown for the 1,079,193 adults of Weaving et al. (2016): Similar age-related decreases for serum albumin albumin have also been reported in smaller studies: Gom et al. 2007 (62,854 […]
In an earlier post I wrote about the association between elevated circulating levels of homocysteine with an increased risk of death from all causes (https://michaellustgarten.com/2017/11/22/homocysteine-and-all-cause-mortality-risk/). I started to post updates in that link, but I’ve decided to move them to here. As of 6/2018, I now have tracked dietary data […]