Mean corpuscular volume (MCV) is one of the variables included in the PhenoAge biological age calculator (see https://michaellustgarten.com/2019/09/09/quantifying-biological-age/). It’s calculated by dividing the fraction of the blood that contains RBCs (hematocrit) by RBCs (MCV = hematocrit/RBC), thereby identifying the average volume contained within red blood cells. Although the MCV reference range […]

Circulating levels of white blood cells (WBCs) are one of the 10 variables used to quantify biological age with PhenoAge (https://michaellustgarten.com/2019/09/09/quantifying-biological-age). The reference range for WBCs is 4.5 – 11 *10^9 cells/L, but within that range, what’s optimal? Several studies have reported that WBCs greater than 5 are associated with an […]

In an earlier post, based on data from the Baltimore Longitidunal Study on Aging (BLSA), I suggested that total white blood cell (WBCs) counts between 3500 to 6000 cells per microliter of blood may be optimal for reducing disease risk and for maximizing longevity (https://michaellustgarten.com/2015/08/13/blood-testing-whats-optimal-for-wbc-levels/). However, within WBCs, neutrophils increase, […]

The reference range for circulating levels of glucose is 70-130 mg/dL. That’s a wide range, so what’s optimal, especially considering that glucose is one of the variables used to quantify of biological age (https://michaellustgarten.com/2019/09/09/quantifying-biological-age)? In the largest study published for this subject (12,455,361 adults), risk of death for all causes […]

In the first half of this presentation, I talk about my contribution to the gut-muscle axis in older adults, and in the second half, my personalized approach to optimal health! Also, here’s the article that corresponds to the presentation: https://www.leafscience.org/the-gut-microbiome-affects-muscle-strength-in-older-adults/ If you’re interested, please have a look at my book!

Circulating levels of calcium can deposit in the coronary arteries (and in other arterial sites), a process that is known as coronary artery calcification (CAC). Arterial calcification is associated with arterial stiffness, which increases risk for adverse cardiovascular events, including cardiovascular disease-related mortality (Allison et al. 2012). Can CAC accumulation be slowed/minimized/prevented? […]