Tag Archives: microbiome

Dietary Fiber And SCFAs Are Relatively Higher in Centenarians-A Pathway To Longevity?

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Papers referenced in the video:
The Age-Accompanied and Diet-Associated Remodeling of the Phospholipid, Amino Acid, and SCFA Metabolism of Healthy Centenarians from a Chinese Longevous Region: A Window into Exceptional Longevity
https://pubmed.ncbi.nlm.nih.gov/36297104/

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
https://pubmed.ncbi.nlm.nih.gov/32082260/

Biohacking the Oral Microbiome

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Bristle Discount Link:
ConquerAging15 https://www.bmq30trk.com/4FL3LK/GTSC3/

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Papers referenced in the video:
Interconnections Between the Oral and Gut Microbiomes: Reversal of Microbial Dysbiosis and the Balance Between Systemic Health and Disease https://pubmed.ncbi.nlm.nih.gov/33652903/

A Brief Introduction to Oral Diseases: Caries, Periodontal Disease, and Oral Cancer
https://tinyurl.com/z45d6djt

Xylitol, mutans streptococci, and dental plaque
https://pubmed.ncbi.nlm.nih.gov/19717413/

Growth Inhibition of Streptococcus mutans with Low Xylitol Concentrations
https://pubmed.ncbi.nlm.nih.gov/18176823/

The antimicrobial activity of essential oils and essential oil components towards oral bacteria https://pubmed.ncbi.nlm.nih.gov/7478759/

Nitrate as a potential prebiotic for the oral microbiome
https://pubmed.ncbi.nlm.nih.gov/32732931/

A Bile Acid (TBMCA) Is Involved In A Mechanism That Reduces Muscle Mass And Strength

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Papers referenced in the video:

Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling https://pubmed.ncbi.nlm.nih.gov/33783283/

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist https://pubmed.ncbi.nlm.nih.gov/23395169/

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice https://pubmed.ncbi.nlm.nih.gov/28650457/

AGE Products Impact Lifespan: Impact Of Hyperglycemia, Kidney Function, And The Microbiome

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Papers referenced in the video:

Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan https://pubmed.ncbi.nlm.nih.gov/18599606/

Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression https://pubmed.ncbi.nlm.nih.gov/17525257/

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N 6-carboxymethyllysine https://pubmed.ncbi.nlm.nih.gov/35241804/

Plasma Carboxymethyl-Lysine, an Advanced Glycation End Product, and All-Cause and Cardiovascular Disease Mortality in Older Community-Dwelling Adults https://pubmed.ncbi.nlm.nih.gov/19682127/

Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community dwelling women https://pubmed.ncbi.nlm.nih.gov/19448391/

Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor KappaB in PBMCs https://pubmed.ncbi.nlm.nih.gov/12606501/

Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans https://pubmed.ncbi.nlm.nih.gov/30823632/

Novel associations between blood metabolites and kidney function among Bogalusa Heart Study and Multi-Ethnic Study of Atherosclerosis participants https://pubmed.ncbi.nlm.nih.gov/31720858/

Serum Carboxymethyl-lysine, a Dominant Advanced Glycation End Product, is Associated with Chronic Kidney Disease: the Baltimore Longitudinal Study of Aging https://pubmed.ncbi.nlm.nih.gov/19853477/

Which Gut Bacteria Are Associated With Poor Health, And How Can We Limit Them?

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Papers referenced in the video:

Human microbiome: an academic update on human body site specific surveillance and its possible role https://pubmed.ncbi.nlm.nih.gov/32524…

Taxonomic signatures of cause-specific mortality risk in human gut microbiome https://pubmed.ncbi.nlm.nih.gov/33976…

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication https://pubmed.ncbi.nlm.nih.gov/32082…

Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification https://pubmed.ncbi.nlm.nih.gov/30563…

Short chain fatty acids in human large intestine, portal, hepatic and venous blood https://pubmed.ncbi.nlm.nih.gov/3678950/

Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study https://pubmed.ncbi.nlm.nih.gov/31370…

The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level https://pubmed.ncbi.nlm.nih.gov/28360…

Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans https://pubmed.ncbi.nlm.nih.gov/29166..

Ergothioneine: A ‘Longevity Vitamin’ With Potential Benefits For Age-Related Outcomes?

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Papers referenced in the video:

Dietary Thiols: A Potential Supporting Strategy against Oxidative Stress in Heart Failure and Muscular Damage during Sports Activity: https://www.ncbi.nlm.nih.gov/pmc/arti…​

Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? https://pubmed.ncbi.nlm.nih.gov/27444…​

Is ergothioneine a ‘longevity vitamin’ limited in the American diet? https://www.ncbi.nlm.nih.gov/pmc/arti…​

Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility: https://pubmed.ncbi.nlm.nih.gov/32295…​

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease: https://pubmed.ncbi.nlm.nih.gov/31672…​

Ergothioneine – a diet‐derived antioxidant with therapeutic potential: https://febs.onlinelibrary.wiley.com/…​

Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances: https://www.nature.com/articles/s4139…

Gut Bacteria Boost Host NAD Metabolism

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Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130883/

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism: https://pubmed.ncbi.nlm.nih.gov/27304511/

Aerobic and resistance exercise training reverses age-dependent decline in NAD + salvage capacity in human skeletal muscle: https://pubmed.ncbi.nlm.nih.gov/31207144/

The Gut Microbiota Affects Health and Aging (Interview with Modern Healthspan): Parts I-VIII

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Here’s the first interview clip (of a series) with Modern Healthspan on YouTube where we discuss the role of the microbiome on health and longevity:

Part II: Skin, Oral Microbiome & Immune System

Part III: Optimal Health with Soluble Fiber

Part IV – Microbial Burden & Hallmarks of Aging

Part V: Spermidine & Immune Support

Part VI: Optimal HDL & LDL

Part VII: Nuts, Seeds & Saturated Fat Intake

Part VII: My Exercise Approach for Longevity

Paper Discussion: Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease

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In the video below, Steve Hill from Lifespan.io and I talk about findings from a recent paper (https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200306) that supports a role for the gut microbiome on Alxheimer’s disease. Check it out!