Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist https://pubmed.ncbi.nlm.nih.gov/23395169/
Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression https://pubmed.ncbi.nlm.nih.gov/17525257/
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N 6-carboxymethyllysine https://pubmed.ncbi.nlm.nih.gov/35241804/
Plasma Carboxymethyl-Lysine, an Advanced Glycation End Product, and All-Cause and Cardiovascular Disease Mortality in Older Community-Dwelling Adults https://pubmed.ncbi.nlm.nih.gov/19682127/
Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community dwelling women https://pubmed.ncbi.nlm.nih.gov/19448391/
Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor KappaB in PBMCs https://pubmed.ncbi.nlm.nih.gov/12606501/
Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans https://pubmed.ncbi.nlm.nih.gov/30823632/
Novel associations between blood metabolites and kidney function among Bogalusa Heart Study and Multi-Ethnic Study of Atherosclerosis participants https://pubmed.ncbi.nlm.nih.gov/31720858/
Serum Carboxymethyl-lysine, a Dominant Advanced Glycation End Product, is Associated with Chronic Kidney Disease: the Baltimore Longitudinal Study of Aging https://pubmed.ncbi.nlm.nih.gov/19853477/
Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study https://pubmed.ncbi.nlm.nih.gov/31370…
The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level https://pubmed.ncbi.nlm.nih.gov/28360…
Dietary Thiols: A Potential Supporting Strategy against Oxidative Stress in Heart Failure and Muscular Damage during Sports Activity: https://www.ncbi.nlm.nih.gov/pmc/arti…
Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? https://pubmed.ncbi.nlm.nih.gov/27444…
Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances: https://www.nature.com/articles/s4139…
Aerobic and resistance exercise training reverses age-dependent decline in NAD + salvage capacity in human skeletal muscle: https://pubmed.ncbi.nlm.nih.gov/31207144/
Germ-free mice (animals don’t have a microbiome) live longer than microbiome-containing mice, but it’s impractical for people to live in a bubble for their entire lifespan. As a more practical approach, which microbiome-derived factors impact lifespan, and can they be modified?
Dietary supplementation with acarbose increases lifespan, and one reason for that may involve reduced circulating levels of glucose, but the other side of that story involves increased gut bacterial production of short chain fatty acids (SCFAs). Whether acarbose will increase lifespan in people is unknown, and with the goal of increasing lifespan, are there other ways to increase SCFAs?
How does the gut microbiome and its metabolic products affect muscle mass, muscle composition, and physical function? In this presentation, I review the evidence, then I present recent data from our group.
Michael Lustgarten 