In terms of all-cause mortality risk, is the reference range for circulating triglycerides (TG, <150 mg/dL) optimal?
A meta-analysis of 38 studies in 360,556 subjects with a median age of 48y and a 12-year follow-up reported lowest all-cause mortality risk for subjects with TG values less than 90 mg/dL (equivalent to ~1 mmol; Liu et al. 2013). As shown below, each successive 90 mg/dL increase was associated with a 12% higher all-cause mortality risk. A person with a value closer to the high end of the reference range, ~150 would have a ~7% increased mortality risk compared someone with a value ~90. In other words, there would be 7 more deaths per 100 total people at a TG value of 150, compared with the death rate for people with values less than 90.
Added importance for the association between TG values less than 90 with all-cause mortality risk come from studies of people who have lived longer than 100 years, centenarians. As shown below, triglyceride values less than 101 mg/dL have been reported in 9 of 11 centenarian studies:
What’s my TG value? As shown below, I’ve measured triglycerides 23 times since 2015, with an average value of 52 mg/dL:
With the goal of keeping triglyceride levels low, are there dietary factors that influence it? When compared with my dietary data, the strongest correlation (r = 0.73, R2=0.5339) is present for triglycerides with my calorie intake. In other words, a higher daily calorie intake is associated with higher levels of triglycerides:
Based on this correlation, should my triglycerides start to rise in the future, a first step would be reducing my average daily calorie intake, which since October 2019 has been ~2550 calories/day.
If you’re interested, please have a look at my book!
Liu J, Zeng FF, Liu ZM, Zhang CX, Ling WH, Chen YM. Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies. Lipids Health Dis. 2013 Oct 29;12:159.
Pingback: Blood Testing: What’s Optimal For Triglycerides? – Maroc Sports News
Thanks Obi z. I have a blog post on triglycerides based on this meta-analysis of 61 studies, and < 90 mg/dL was associated with lowest all-cause mortality risk (https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-12-159). I'd bet that even lower may be optimal, as values ~50 are found in youth and in athletes.
There’s a new study (2020) that shows a dose-response association of triglyceride levels with all-cause mortality, with nadir at approximately 135 mg/dL:
It just gets more confusing…