Homocysteine Increases During Aging, But Can Be Reduced With Diet And Targeted Supplementation

Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130…

Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels: https://pubmed.ncbi.nlm.nih.gov/27567…

Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study: https://pubmed.ncbi.nlm.nih.gov/7474221/

Total plasma homocysteine values among elderly subjects: findings from the Maracaibo Aging Study: https://pubmed.ncbi.nlm.nih.gov/16959…

Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies: https://www.ncbi.nlm.nih.gov/pmc/arti…

Hyperhomocysteinemia and risk of incident cognitive outcomes: An updated dose-response meta-analysis of prospective cohort studies: https://pubmed.ncbi.nlm.nih.gov/30826…

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies: https://www.nature.com/articles/s4159…

Michael Lustgarten

Ph.D, Physiology, University of Texas Health Science Center at San Antonio, 2009 B.S., Biochemistry, Queens College, 2003 B.A, English Textual Studies, 1994, Syracuse University

3 thoughts on “Homocysteine Increases During Aging, But Can Be Reduced With Diet And Targeted Supplementation

  1. Hi Mike,
    Great video, thanks for taking all the time to make these. You are doing the hard work others don’t seem to be interested in.
    Your increased daily protein should have made your homocysteine worse. I wonder if you are serine deficient?
    https://academic.oup.com/ajcn/article/80/3/674/4690546
    What did you do earlier this year that improved your lymphocyte count so much?

    1. My lymphocyte levels have always been in the ~2000 range, and relatively high as a %.

      With a quick look at my data for diet correlations with lymphocyte#s, there aren’t any strong correlations, so it’s tough to say how to raise them.

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