Homocysteine Increases During Aging, But Can Be Reduced With Diet And Targeted Supplementation

Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130…

Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels: https://pubmed.ncbi.nlm.nih.gov/27567…

Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study: https://pubmed.ncbi.nlm.nih.gov/7474221/

Total plasma homocysteine values among elderly subjects: findings from the Maracaibo Aging Study: https://pubmed.ncbi.nlm.nih.gov/16959…

Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies: https://www.ncbi.nlm.nih.gov/pmc/arti…

Hyperhomocysteinemia and risk of incident cognitive outcomes: An updated dose-response meta-analysis of prospective cohort studies: https://pubmed.ncbi.nlm.nih.gov/30826…

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies: https://www.nature.com/articles/s4159…


5 thoughts on “Homocysteine Increases During Aging, But Can Be Reduced With Diet And Targeted Supplementation

    1. Michael Lustgarten Post author

      My lymphocyte levels have always been in the ~2000 range, and relatively high as a %.

      With a quick look at my data for diet correlations with lymphocyte#s, there aren’t any strong correlations, so it’s tough to say how to raise them.


  1. Greg

    Hi Dr. Lustgarten. I love all of your videos and the amount of work you put in to providing data-driven analysis.

    Related to this particular topic, what could cause chronic, very high B12 levels (between 900 and 2200) without supplementation? This has been the case for the last 30 years. Every doctor I have asked about this indicates that this is not a concern since the B12 is not low— but they can’t explain this. Along with this comes a high folate level and high hematocrit and hemoglobin.

    This high B12 has been a mystery. Nothing I have read has given me any insight. The only thing I’ve come across indicates this might be a sign of low thiamine intake, but that was not a research-based conclusion.

    Could there be an issue with B12 not being used properly and thus building up in the blood? Why would this be the case?

    Thanks for any input you might have on this mystery! Your knowledge in these areas is pretty encyclopedic.



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