Tag Archives: Folate

Serine + Vitamin B6: The Best Way To Reduce Homocysteine? (Also, Homocysteine Activates mTORC1)

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links:
NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout

Green Tea: https://www.ochaandco.com/?ref=conqueraging

Oral Microbiome: https://www.bristlehealth.com/?ref=michaellustgarten

Epigenetic Testing: https://bit.ly/3Rken0n
Use Code: CONQUERAGING!

At-Home Blood Testing: https://getquantify.io/mlustgarten

Diet Tracking: https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

If you’d like to support the channel, you can do that with the website, Buy Me A Coffee:
https://www.buymeacoffee.com/mlhnrca

Conquer Aging Or Die Trying Merch! https://my-store-d4e7df.creator-spring.com/


Papers referenced in the video:
The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice
https://pubmed.ncbi.nlm.nih.gov/28148781/

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
https://www.nature.com/articles/nature08221

Type 2 diabetes – unmet need, unresolved pathogenesis, mTORC1-centric paradigm
https://pubmed.ncbi.nlm.nih.gov/32128655/

Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey
https://pubmed.ncbi.nlm.nih.gov/10075334/

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927493/

(Supplementary Table 6) Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors
https://www.nature.com/articles/s43587-022-00193-0

Advertisement

Homocysteine Increases During Aging, But Can Be Reduced With Diet And Targeted Supplementation

Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130…

Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels: https://pubmed.ncbi.nlm.nih.gov/27567…

Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study: https://pubmed.ncbi.nlm.nih.gov/7474221/

Total plasma homocysteine values among elderly subjects: findings from the Maracaibo Aging Study: https://pubmed.ncbi.nlm.nih.gov/16959…

Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies: https://www.ncbi.nlm.nih.gov/pmc/arti…

Hyperhomocysteinemia and risk of incident cognitive outcomes: An updated dose-response meta-analysis of prospective cohort studies: https://pubmed.ncbi.nlm.nih.gov/30826…

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies: https://www.nature.com/articles/s4159…