Tag Archives: Diet

How Many Calories Are Optimal For Health?

Quantifying Biological Age: Blood Test #5 in 2021

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Links to biological age calculators:

Levine’s PhenoAge calculator is embedded as an Excel file: https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

aging.ai

Papes referenced in the video:

Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies https://www.bmj.com/content/348/bmj.g1903

Fisetin is a senotherapeutic that extends health and lifespan https://pubmed.ncbi.nlm.nih.gov/30279143/

Which Gut Bacteria Are Associated With Poor Health, And How Can We Limit Them?

For more info, join us on Patreon! https://www.patreon.com/MichaelLustga…

Papers referenced in the video:

Human microbiome: an academic update on human body site specific surveillance and its possible role https://pubmed.ncbi.nlm.nih.gov/32524…

Taxonomic signatures of cause-specific mortality risk in human gut microbiome https://pubmed.ncbi.nlm.nih.gov/33976…

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication https://pubmed.ncbi.nlm.nih.gov/32082…

Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification https://pubmed.ncbi.nlm.nih.gov/30563…

Short chain fatty acids in human large intestine, portal, hepatic and venous blood https://pubmed.ncbi.nlm.nih.gov/3678950/

Age-Associated Changes in Gut Microbiota and Dietary Components Related with the Immune System in Adulthood and Old Age: A Cross-Sectional Study https://pubmed.ncbi.nlm.nih.gov/31370…

The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level https://pubmed.ncbi.nlm.nih.gov/28360…

Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans https://pubmed.ncbi.nlm.nih.gov/29166..

Are There Foods That Can Increase NAD? (Part II)

Papers referenced in the video:

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence: https://pubmed.ncbi.nlm.nih.gov/29514…

NAD and the aging process: Role in life, death and everything in between: https://pubmed.ncbi.nlm.nih.gov/27825…

Flavonoids as inhibitors of human CD38: https://pubmed.ncbi.nlm.nih.gov/21641…

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome: https://pubmed.ncbi.nlm.nih.gov/23172…

Characterization of Anthocyanins and Proanthocyanidins in Some Cultivars of Ribes, Aronia, and Sambucus and Their Antioxidant Capacity: https://pubmed.ncbi.nlm.nih.gov/15612…

Flavonoid glycosides and antioxidant capacity of various blackberry, blueberry and red grape genotypes determined by high-performance liquid chromatography/mass spectrometry: https://onlinelibrary.wiley.com/doi/1…

USDA Database for the Flavonoid Content of Selected Foods: https://www.ars.usda.gov/arsuserfiles… Large changes in NAD levels associated with CD38 expression during HL-60 cell differentiation: https://pubmed.ncbi.nlm.nih.gov/24216…

Effect of genotype and environment on flavonoid concentration and profile of black sorghum grains (incorrectly indicated as Dykes et al. 2013): https://www.sciencedirect.com/science…

Luteolinidin Protects the Post-ischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H): https://jpet.aspetjournals.org/conten…SHOW LESS

HDL Update: Age-Related Changes, All-Cause Mortality Risk, And Progress Towards The Optimal Range

In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis.

In addition, I’ve tested my HDL 2 more times since November 2020, so how’s my progress for getting it into the optimal range? Also, I attempt to derive clinical significance by identifying correlations for higher HDL with lower Lp(a) and hs-CRP.

Video link: https://www.youtube.com/watch?v=MUuKlpyvZaU

Kidney Function: The Missing Link In The TMAO-Health And Disease Story?

Animal products, including meat, cheese, and eggs contain carnitine and choline, metabolites that are converted by gut bacteria into TMA, which is then converted by the liver into TMAO. Plasma levels of TMAO are associated with an increased risk of disease and death, so should we limit intake of these animal products? Separately, fish contains relatively high levels of TMAO, and blood levels of TMAO spike after fish consumption, but there is a decreased all-cause mortality risk for fish consumers. To explain these disparate findings, other factors may be involved in the TMAO-health and disease story. In the video, I discuss the impact of kidney function on plasma levels of TMAO, disease and mortality risk.

Quantifying Biological Age: Blood Test #5 in 2020

My latest blood test results are in-how’s my biological age?

In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them with diet going forward.

Dietary AGE Products Impact Insulin Resistance, Inflammation, And Lifespan

Cooking foods at temperatures higher than boiling produces advanced glycation end (AGE) products, which induce insulin resistance and inflammation, and shorten lifespan in mice. Similar data exists in humans for the effect of dietary AGE products on insulin resistance and inflammation, and a higher dietary AGE product intake is associated with cancer in both men and women. Accordingly, reducing dietary AGE product intake may be an important strategy for improving health and increasing lifespan in people.