Tag Archives: lifespan

Quantifying Biological Age: Blood Test #1 in 2023

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The Excel file to calculate Levine’s Biological Age is embedded in this link from my website:
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Papers referenced in the video:
The Gamma Gap and All-Cause Mortality
https://pubmed.ncbi.nlm.nih.gov/26629820/

Liver enzymes and risk of all-cause mortality in general populations: a systematic review and meta-analysis
https://pubmed.ncbi.nlm.nih.gov/24585856/

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Green Tea Is Associated With Reduced All-Cause Mortality Risk

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Papers referenced in the video:
Green tea consumption and cause-specific mortality: Results from two prospective cohort studies in China
https://pubmed.ncbi.nlm.nih.gov/28135196/

Tea consumption and mortality of all cancers, CVD and all causes: a meta-analysis of eighteen prospective cohort studies
https://pubmed.ncbi.nlm.nih.gov/26202661/

Green tea consumption and mortality in Japanese men and women: a pooled analysis of eight population-based cohort studies in Japan
https://pubmed.ncbi.nlm.nih.gov/31392470/

Resting Heart Rate, Heart Rate Variability: What’s Optimal, 1600+ Days of Data

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Papers referenced in the video
Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults
https://pubmed.ncbi.nlm.nih.gov/32023264/

Heart rate variability with photoplethysmography in 8 million individuals: a cross-sectional study
https://pubmed.ncbi.nlm.nih.gov/33328029/

Blood Test #7 in 2022: Diet Composition

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Methionine Restriction Extends Lifespan: Roles For SCFAs And FGF21, But Not Calorie Restriction

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Papers referenced in the video:
Dietary Methionine via Dose-Dependent Inhibition of Short-Chain Fatty Acid Production Capacity Contributed to a Potential Risk of Cognitive Dysfunction in Mice
https://pubmed.ncbi.nlm.nih.gov/36413479/

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age
https://pubmed.ncbi.nlm.nih.gov/19414512/

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice
https://pubmed.ncbi.nlm.nih.gov/31195972/

Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
https://pubmed.ncbi.nlm.nih.gov/15924568/

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
https://pubmed.ncbi.nlm.nih.gov/24245565/

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
https://pubmed.ncbi.nlm.nih.gov/23066506/

Epigenetic Tests #1 and 2: Horvath, Hannum, DunedinPACE

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Papers referenced in the video:
Underlying features of epigenetic aging clocks in vivo and in vitro
https://pubmed.ncbi.nlm.nih.gov/32930491/

DNA methylation‐based measures of biological age: meta‐analysis predicting time to death
https://pubmed.ncbi.nlm.nih.gov/27690265/

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
https://pubmed.ncbi.nlm.nih.gov/26678252/

DunedinPACE, a DNA methylation biomarker of the pace of aging
https://pubmed.ncbi.nlm.nih.gov/35029144/

Effect of Long-Term Caloric Restriction on DNA Methylation Measures of BiologicalAging in Healthy Adults: CALERIE™ Trial Analysis
https://www.medrxiv.org/content/10.1101/2021.09.21.21263912v1.full.pdf

Glycine + N-Acetyl Cysteine Supplementation Increases Lifespan

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Paper referenced in the video:
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/35975308/

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in
Mice Increases Length of Life by Correcting Glutathione
Deficiency, Oxidative Stress, Mitochondrial Dysfunction,
Abnormalities in Mitophagy and Nutrient Sensing,
and Genomic Damage
https://pubmed.ncbi.nlm.nih.gov/35268089/

Glycine and N-acetylcysteine (GlyNAC) supplementation in
older adults improves glutathione deficiency, oxidative
stress, mitochondrial dysfunction, inflammation, insulin
resistance, endothelial dysfunction, genotoxicity, muscle
strength, and cognition: Results of a pilot clinical trial
https://pubmed.ncbi.nlm.nih.gov/33783984/

Lifespan Extension With Calorie Restriction, Fasting, And Circadian Alignment

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Papers referenced in the video:
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice
https://www.nature.com/articles/s42255-021-00466-9

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
https://pubmed.ncbi.nlm.nih.gov/35511946/

Lithocholic Acid: A Gut Bacterial Metabolite That Extends Lifespan

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Papers referenced in the video:
Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors https://www.nature.com/articles/s43587-022-00193-0

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism https://pubmed.ncbi.nlm.nih.gov/30157432/

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production https://pubmed.ncbi.nlm.nih.gov/11371619/

Alterations in xenobiotic metabolism in the long-lived Little mice https://pubmed.ncbi.nlm.nih.gov/17521389/

Bile Acids: A Communication Channel in the Gut-Brain Axis https://pubmed.ncbi.nlm.nih.gov/33085065/

Lithocholic acid significantly improves the survival of Drosophila melanogaster https://pubmed.ncbi.nlm.nih.gov/30051966/

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians https://pubmed.ncbi.nlm.nih.gov/34325466/

Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans https://pubmed.ncbi.nlm.nih.gov/30089729/

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes https://pubmed.ncbi.nlm.nih.gov/20622262/

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians https://pubmed.ncbi.nlm.nih.gov/34325466/