Tag Archives: lifespan

Spermidine Impacts Health and Longevity

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Papers referenced in the video:

Polyamine-rich food decreases age-associated pathology and mortality in aged mice https://pubmed.ncbi.nlm.nih.gov/19735716/

Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats https://pubmed.ncbi.nlm.nih.gov/32285289/

Cardioprotection and lifespan extension by the natural polyamine spermidine https://pubmed.ncbi.nlm.nih.gov/27841876/

Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy https://pubmed.ncbi.nlm.nih.gov/28386016/

Higher spermidine intake is linked to lower mortality: a prospective population-based study https://pubmed.ncbi.nlm.nih.gov/29955838/

Polyamines in aging and disease https://pubmed.ncbi.nlm.nih.gov/21869457/

Dietary spermidine improves cognitive function https://pubmed.ncbi.nlm.nih.gov/33852843/

The positive effect of spermidine in older adults suffering from dementia : First results of a 3-month trial https://pubmed.ncbi.nlm.nih.gov/33211152/

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial https://pubmed.ncbi.nlm.nih.gov/30388439/

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline https://pubmed.ncbi.nlm.nih.gov/29315079/

A review of dietary polyamines: Formation, implications forgrowth and health and occurrence in foods https://www.sciencedirect.com/science/article/abs/pii/S0308814604002961

In vitro digestion of spermidine and amino acids in fresh and processed Agaricus bisporus mushroom https://pubmed.ncbi.nlm.nih.gov/33233206/

Decrease in polyamines with aging and their ingestion from food and drink https://pubmed.ncbi.nlm.nih.gov/16428322/

Fasting Drives The Geroprotective Effects Of A Calorie-Restricted Diet

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Paper referenced in the video:

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice https://www.nature.com/articles/s42255-021-00466-9

Attempting To Further Reduce Biological Age: hs-CRP

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Levine’s Biological age calculator is embedded as an Excel file in this link: https://michaellustgarten.wordpress.com/2019/09/09/quantifying-biological-age/

Papers referenced in the video:

The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population https://immunityageing.biomedcentral.com/articles/10.1186/s12979-018-0126-7

Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies https://pubmed.ncbi.nlm.nih.gov/33152050/

65 – 100% Lifespan Extension In Drosophila: A Conversation With Dr. Michael Rose

Part II: Use Of Machine Learning In Longevity Science: A Conversation With Dr. Michael Rose

Part III: Which Diet Is Optimal For Health: The Evolutionary Perspective

Full, 80-minute, unedited video:

Papers referenced in the videos:

Can human aging be postponed? https://pubmed.ncbi.nlm.nih.gov/10614072/

Paper referenced in the video: Diet and Botanical Supplementation: Combination Therapy for Healthspan Improvement? https://pubmed.ncbi.nlm.nih.gov/32924860/

Dr. Rose’s website: https://55theses.org/

Insulin Sensitivity Is A Hallmark Of Longevity

HOMA calculator: https://www.omnicalculator.com/health…

Papers referenced in the video:

Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice https://pubmed.ncbi.nlm.nih.gov/24175…

Glucose regulation and oxidative stress in healthy centenarians https://pubmed.ncbi.nlm.nih.gov/12543…

Distribution of blood glucose and prevalence of diabetes among centenarians and oldest-old in China: based on the China Hainan Centenarian Cohort Study and China Hainan Oldest-old Cohort Study https://pubmed.ncbi.nlm.nih.gov/32643…

Prevalence and Ethnic Pattern of Diabetes and Prediabetesin China in 2013 https://pubmed.ncbi.nlm.nih.gov/28655…

Families enriched for exceptional longevity also have increased health-span: findings from the long life family study https://pubmed.ncbi.nlm.nih.gov/24350…

SIRT6 Positively Affects The Hallmarks Of Aging And Extends Lifespan

Papers referenced in the video:

Sirtuins, Healthspan, and Longevity in Mammals https://www.sciencedirect.com/science…

Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH https://pubmed.ncbi.nlm.nih.gov/24011…

Resveratrol improves health and survival of mice on a high-calorie diet https://pubmed.ncbi.nlm.nih.gov/17086…

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice https://pubmed.ncbi.nlm.nih.gov/20974…

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer https://www.nature.com/articles/ncomm…

Restoration of energy homeostasis by SIRT6 extends healthy lifespan https://pubmed.ncbi.nlm.nih.gov/34050…

The sirtuin SIRT6 regulates lifespan in male mice https://pubmed.ncbi.nlm.nih.gov/22367…

SIRT6 in Senescence and Aging-Related Cardiovascular Diseases https://pubmed.ncbi.nlm.nih.gov/33855…

Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling https://pubmed.ncbi.nlm.nih.gov/26940…

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6 https://pubmed.ncbi.nlm.nih.gov/27101…

A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes https://pubmed.ncbi.nlm.nih.gov/33920…

Acute Exercise Leads to Regulation of Telomere Associated Genes and MicroR A Expression in Immune Cells https://pubmed.ncbi.nlm.nih.gov/24752…

The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men https://pubmed.ncbi.nlm.nih.gov/32919…

High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?

Papers referenced in the video:

FGF21 and Chronic Kidney Disease: https://www.sciencedirect.com/science…

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21: https://pubmed.ncbi.nlm.nih.gov/18585…

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877…

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression: https://pubmed.ncbi.nlm.nih.gov/31773…

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses: https://pubmed.ncbi.nlm.nih.gov/28552…

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging: https://pubmed.ncbi.nlm.nih.gov/33131…

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue: https://pubmed.ncbi.nlm.nih.gov/30043…

Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals: https://pubmed.ncbi.nlm.nih.gov/26042…

Lower All-Cause, Cardiovascular, and Cancer Mortality in Centenarians’ Offspring: https://pubmed.ncbi.nlm.nih.gov/15571…

Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study: https://pubmed.ncbi.nlm.nih.gov/20398…

HDL Update: Age-Related Changes, All-Cause Mortality Risk, And Progress Towards The Optimal Range

In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis.

In addition, I’ve tested my HDL 2 more times since November 2020, so how’s my progress for getting it into the optimal range? Also, I attempt to derive clinical significance by identifying correlations for higher HDL with lower Lp(a) and hs-CRP.

Video link: https://www.youtube.com/watch?v=MUuKlpyvZaU