In the video below, Steve Hill from Lifespan.io and I talk about findings from a recent paper (https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200306) that supports a role for the gut microbiome on Alxheimer’s disease. Check it out!
Germ-free mice (animals don’t have a microbiome) live longer than microbiome-containing mice, but it’s impractical for people to live in a bubble for their entire lifespan. As a more practical approach, which microbiome-derived factors impact lifespan, and can they be modified? Dietary supplementation with acarbose increases lifespan, and one reason […]
CD8+ T cells are a subset of lymphocytes that play a major role in antiviral defense (Kulinski et al. 2013). However, recently published evidence shows reduced levels of circulating CD8+ T cells in people infected with SARS-CoV-2 (Zheng et al. 2020, Wang et al. 2020; HC= healthy controls, NCP = patients with COVID-19 […]
Paper #1: Here I propose that the poor muscle composition (muscle that has fat in it) found in older adults may be related to an increased systemic microbial burden: https://www.ncbi.nlm.nih.gov/pubmed/29030163 Paper #2: In this review, we discuss the emerging gut-muscle axis: https://www.ncbi.nlm.nih.gov/pubmed/29058056 If you’re interested, please have a […]
Here’s my book, available now! https://www.amazon.com/dp/B01G48A88A
Our story begins with Michael Rose, who used an experimental evolution approach to breed flies that live more than 2-fold longer than controls (Rose 1999). In contrast with the one gene at a time knockout or overexpression strategy that is ubiquitous in modern biology, Rose separated initially genetically homogeneous flies into […]