Category Archives: Homocysteine

High Mushroom Intake, High Homocysteine?

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Serine + Vitamin B6: No Effect On Homocysteine (Test #2)

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Paper referenced in the video: Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels https://pubmed.ncbi.nlm.nih.gov/27567458/

Serine + Vitamin B6: The Best Way To Reduce Homocysteine? (Also, Homocysteine Activates mTORC1)

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Papers referenced in the video:
The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice
https://pubmed.ncbi.nlm.nih.gov/28148781/

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
https://www.nature.com/articles/nature08221

Type 2 diabetes – unmet need, unresolved pathogenesis, mTORC1-centric paradigm
https://pubmed.ncbi.nlm.nih.gov/32128655/

Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey
https://pubmed.ncbi.nlm.nih.gov/10075334/

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927493/

(Supplementary Table 6) Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors
https://www.nature.com/articles/s43587-022-00193-0

Will Glycine Supplementation Reduce Homocysteine?

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Papers referenced in the video:
Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey
https://pubmed.ncbi.nlm.nih.gov/10075334/

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies
https://pubmed.ncbi.nlm.nih.gov/28684797/

Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies
https://pubmed.ncbi.nlm.nih.gov/31069230/

Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases
https://pubmed.ncbi.nlm.nih.gov/31208147/

Link to an earlier experiment for betaine (TMG) on homocysteine:
Reducing Homocysteine? Updates.
https://michaellustgarten.com/2018/03/23/reducing-homocysteine-updates/

The Cholesterol-DHEA-S Experiment; A Role For Thyroid Function on DHEA-S And/Or Homocysteine?

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Papers referenced in the video:
Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives
https://pubmed.ncbi.nlm.nih.gov/31201927/

Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow up study in a community based cohort (Tanushimaru study)
https://pubmed.ncbi.nlm.nih.gov/18422949/

Alteration of serum dehydroepiandrosterone and its sulfated derivative in hypothyroidism
https://www.ipinnovative.com/journals/IJCBR/article-full-text/7778

Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism
https://pubmed.ncbi.nlm.nih.gov/11523906/

Serum Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate, and Pregnenolone Sulfate Concentrations in Patients with Hyperthyroidism and Hypothyroidism
https://pubmed.ncbi.nlm.nih.gov/10759476/

Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism
https://pubmed.ncbi.nlm.nih.gov/10475887/

Homocysteine Increases During Aging, But Can Be Reduced With Diet And Targeted Supplementation

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Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130…​

Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels: https://pubmed.ncbi.nlm.nih.gov/27567…​

Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study: https://pubmed.ncbi.nlm.nih.gov/7474221/​

Total plasma homocysteine values among elderly subjects: findings from the Maracaibo Aging Study: https://pubmed.ncbi.nlm.nih.gov/16959…​

Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies: https://www.ncbi.nlm.nih.gov/pmc/arti…​

Hyperhomocysteinemia and risk of incident cognitive outcomes: An updated dose-response meta-analysis of prospective cohort studies: https://pubmed.ncbi.nlm.nih.gov/30826…​

Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies: https://www.nature.com/articles/s4159…