Crissman Loomis is a former AI programmer, mathematician, health and longevity researcher, and the owner/operator of unaging.com
Timestamps: 0:00 Intro 1:08 5 Lifestyle Factors That Increase Life Expectancy To Around 90y 4:08 All-Cause Mortality (ACM) Data As A Guide To Potentially Get Beyond 90y 5:30 Incorporating Biomarkers Of Organ And Systemic Function For More Specificity 7:50 Optimizing Exercise Dosage 10:38 Using Biomarkers As A Strategy To Optimize Exercise Dose 12:00 Mike’s Exercise Specifics 16:05 Criss’s Exercise Dose 16:30 Titrating Exercise Dose 30:11 Mobility, Flexibility, Balance Training 35:35 Mobile Phenotype/Youthful Movement Pattern 39:25 Criss’s Diet 43:45 Is Calorie Restriction More Important Than Diet Composition? 54:45 Fasting 56:20 BMI Greater Than 25 Is Optimal Based On ACM Data? 1:00:30 Increased Lifespan With Fasting + CR + Circadian Alignment
1:09:30 Criss’s Marathon Training-Impact on CV Biomarkers?
Papers referenced in the video: Mortality rate and longevity of food-restricted exercising male rats: a reevaluation (Exercise increases average, but only CR increases average and maximal lifespan) https://pubmed.ncbi.nlm.nih.gov/9049716/
Female and male US Olympic athletes live 5 years longer than their general population counterparts: a study of 8124 former US Olympians https://pubmed.ncbi.nlm.nih.gov/32727712/
Resistance Training and Mortality Risk: A Systematic Review and Meta-Analysis (Lowest ACM risk for 75 minutes, but an increased ACM risk for greater than 170 minutes/week) https://pubmed.ncbi.nlm.nih.gov/35599175/
Papers referenced in the video: Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials https://pubmed.ncbi.nlm.nih.gov/37041200/
Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging https://pubmed.ncbi.nlm.nih.gov/34117761/
Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality The Hordaland Health Study https://pubmed.ncbi.nlm.nih.gov/26823439/
———————————————————————————————————————– Papers referenced in the video: Age-related changes in clinical parameters and their associations with common complex diseases https://pubmed.ncbi.nlm.nih.gov/26623014/
Glycated haemoglobin A1c as a risk factor of cardiovascular outcomes and all-cause mortality in diabetic and non-diabetic populations: a systematic review and meta-analysis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642750/
——————————————————————————————————————————-Papers referenced in the video: Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study https://pubmed.ncbi.nlm.nih.gov/12376505/
Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives https://pubmed.ncbi.nlm.nih.gov/31201927/
Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors https://pubmed.ncbi.nlm.nih.gov/37118062/
Michael Lustgarten 