Tag Archives: Glutathione

Metabolite Ratios As An Index Of Oxidative Stress

Leave a reply

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links:
At-Home Metabolomics: https://iollo.com?ref=michael-lustgarten Use Code: CONQUERAGING At Checkout

Telomere Length, Epigenetic Testing: Trudiagnostic.pxf.io/R55XDv
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout

Green Tea: https://www.ochaandco.com/?ref=conqueraging

Oral Microbiome (Enter Code: ConquerAging): https://www.bristlehealth.com/?ref=michaellustgarten

At-Home Blood Testing (including ApoB): https://getquantify.io/mlustgarten

Diet Tracking: https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

If you’d like to support the channel, you can do that with the website, Buy Me A Coffee: https://www.buymeacoffee.com/mlhnrca

Conquer Aging Or Die Trying Merch! https://my-store-d4e7df.creator-spring.com/

——————————————————————————————————————————-Papers referenced in the video:

Hallmarks of aging: An expanding universe
https://pubmed.ncbi.nlm.nih.gov/36599349/

The multifaceted role of reactive oxygen species in tumorigenesis
https://pubmed.ncbi.nlm.nih.gov/32358622/

The Potential of a Protein Model Synthesized Absent of Methionine
https://www.mdpi.com/1420-3049/27/12/3679

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors
https://pubmed.ncbi.nlm.nih.gov/37118062/

Serine + Vitamin B6: The Best Way To Reduce Homocysteine? (Also, Homocysteine Activates mTORC1)

2 Replies

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links:
NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout

Green Tea: https://www.ochaandco.com/?ref=conqueraging

Oral Microbiome: https://www.bristlehealth.com/?ref=michaellustgarten

Epigenetic Testing: https://bit.ly/3Rken0n
Use Code: CONQUERAGING!

At-Home Blood Testing: https://getquantify.io/mlustgarten

Diet Tracking: https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

If you’d like to support the channel, you can do that with the website, Buy Me A Coffee:
https://www.buymeacoffee.com/mlhnrca

Conquer Aging Or Die Trying Merch! https://my-store-d4e7df.creator-spring.com/

Papers referenced in the video:
The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice
https://pubmed.ncbi.nlm.nih.gov/28148781/

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
https://www.nature.com/articles/nature08221

Type 2 diabetes – unmet need, unresolved pathogenesis, mTORC1-centric paradigm
https://pubmed.ncbi.nlm.nih.gov/32128655/

Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey
https://pubmed.ncbi.nlm.nih.gov/10075334/

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927493/

(Supplementary Table 6) Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors
https://www.nature.com/articles/s43587-022-00193-0

Glycine + N-Acetyl Cysteine Supplementation Increases Lifespan

Leave a reply

Join us on Patreon!
https://www.patreon.com/MichaelLustgartenPhD

Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Cronometer Discount Link (Daily diet tracking):
https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

Support the channel with Buy Me A Coffee!
https://www.buymeacoffee.com/mlhnrca

Paper referenced in the video:
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/35975308/

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in
Mice Increases Length of Life by Correcting Glutathione
Deficiency, Oxidative Stress, Mitochondrial Dysfunction,
Abnormalities in Mitophagy and Nutrient Sensing,
and Genomic Damage
https://pubmed.ncbi.nlm.nih.gov/35268089/

Glycine and N-acetylcysteine (GlyNAC) supplementation in
older adults improves glutathione deficiency, oxidative
stress, mitochondrial dysfunction, inflammation, insulin
resistance, endothelial dysfunction, genotoxicity, muscle
strength, and cognition: Results of a pilot clinical trial
https://pubmed.ncbi.nlm.nih.gov/33783984/

Ergothioneine: A ‘Longevity Vitamin’ With Potential Benefits For Age-Related Outcomes?

2 Replies

Papers referenced in the video:

Dietary Thiols: A Potential Supporting Strategy against Oxidative Stress in Heart Failure and Muscular Damage during Sports Activity: https://www.ncbi.nlm.nih.gov/pmc/arti…​

Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? https://pubmed.ncbi.nlm.nih.gov/27444…​

Is ergothioneine a ‘longevity vitamin’ limited in the American diet? https://www.ncbi.nlm.nih.gov/pmc/arti…​

Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility: https://pubmed.ncbi.nlm.nih.gov/32295…​

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease: https://pubmed.ncbi.nlm.nih.gov/31672…​

Ergothioneine – a diet‐derived antioxidant with therapeutic potential: https://febs.onlinelibrary.wiley.com/…​

Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances: https://www.nature.com/articles/s4139…

Glutathione Restoration Improves Hallmarks Of Aging in Older Adults

2 Replies

Papers referenced int the video:

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation: https://pubmed.ncbi.nlm.nih.gov/21795…​

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial: https://pubmed.ncbi.nlm.nih.gov/33783…​

Glutathione declines during aging (Age-related changes in the glutathione redox system): https://pubmed.ncbi.nlm.nih.gov/11835…