Papers referenced in the video: Dietary Thiols: A Potential Supporting Strategy against Oxidative Stress in Heart Failure and Muscular Damage during Sports Activity:…​ Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?…​ Is ergothioneine a ‘longevity vitamin’ limited […]

A reduced mortality risk and an increased lifespan has been reported for people who have APOE2 alleles, when compared with APOE3 or APOE4, but beyond associations, data for lifespan in APOE-expressing mice was recently reported, evidence that supports a causative role for APOE on longevity.

Mean corpuscular volume (MCV) is one of the 10 variables included in the biological age calculator, PhenoAge (see It’s calculated by dividing the fraction of the blood that contains RBCs (hematocrit) by RBCs (MCV = hematocrit/RBC), thereby identifying the average volume contained within red blood cells. Although the MCV reference […]

Alkaline phosphatase (ALP) is one of the 10 variables used to quantify biological age with PhenoAge ( The reference range for alkaline phosphatase is 20 – 140 IU/L*, but within that range, what’s optimal? Two separate meta-analyses have investigated the association between serum levels of ALP with risk of death […]

Within the body, meat, grains, and nuts are generally acid-forming, whereas vegetables and fruits are alkaline-forming. Is the distinction between whether your diet is acid- or alkaline-forming important for optimal health and lifespan? In an earlier post, I discussed the importance of PRAL (potential renal acid load) by correlating it […]