Tag Archives: centenarian

Acylcarnitines Increase During Aging, And Are Associated With Poor Health

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Papers referenced in the video:
Hallmarks of aging: An expanding universe
https://pubmed.ncbi.nlm.nih.gov/36599349/

Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718505/

Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials https://pubmed.ncbi.nlm.nih.gov/35710135/

Metabolomics signature improves the prediction of cardiovascular events in elderly subjects https://pubmed.ncbi.nlm.nih.gov/24468136/

Systemic and central nervous system metabolic alterations in Alzheimer’s disease https://pubmed.ncbi.nlm.nih.gov/31779690/

The association between plasma metabolites and future risk of all-cause mortality https://pubmed.ncbi.nlm.nih.gov/35796403/

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors
https://pubmed.ncbi.nlm.nih.gov/37118062/

Albumin, CRP, and Creatinine: Better Markers Of Longevity Than Lipoproteins And Glycemic Status

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Use Code: ConquerAging At Checkout

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Use Code: CONQUERAGING

Oral Microbiome (Enter Code: ConquerAging): https://www.bristlehealth.com/?ref=michaellustgarten

Green Tea: https://www.ochaandco.com/?ref=conqueraging

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Circulating Levels Of Omega-3 Fatty Acids (EPA, DHA) Decline During Aging

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——————————————————————————————————————————-Papers referenced in the video:

Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid and docosahexaenoic acid
https://pubmed.ncbi.nlm.nih.gov/22361189/

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors
https://pubmed.ncbi.nlm.nih.gov/37118062/

Blood n-3 fatty acid levels and total and cause specific mortality from 17 prospective studies
https://pubmed.ncbi.nlm.nih.gov/33888689/

Dietary Fiber And SCFAs Are Relatively Higher in Centenarians-A Pathway To Longevity?

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Papers referenced in the video:
The Age-Accompanied and Diet-Associated Remodeling of the Phospholipid, Amino Acid, and SCFA Metabolism of Healthy Centenarians from a Chinese Longevous Region: A Window into Exceptional Longevity
https://pubmed.ncbi.nlm.nih.gov/36297104/

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
https://pubmed.ncbi.nlm.nih.gov/32082260/

Lithocholic Acid: A Gut Bacterial Metabolite That Extends Lifespan

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Papers referenced in the video:
Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors https://www.nature.com/articles/s43587-022-00193-0

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism https://pubmed.ncbi.nlm.nih.gov/30157432/

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production https://pubmed.ncbi.nlm.nih.gov/11371619/

Alterations in xenobiotic metabolism in the long-lived Little mice https://pubmed.ncbi.nlm.nih.gov/17521389/

Bile Acids: A Communication Channel in the Gut-Brain Axis https://pubmed.ncbi.nlm.nih.gov/33085065/

Lithocholic acid significantly improves the survival of Drosophila melanogaster https://pubmed.ncbi.nlm.nih.gov/30051966/

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians https://pubmed.ncbi.nlm.nih.gov/34325466/

Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans https://pubmed.ncbi.nlm.nih.gov/30089729/

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes https://pubmed.ncbi.nlm.nih.gov/20622262/

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians https://pubmed.ncbi.nlm.nih.gov/34325466/

Centenarian Blood Test Analysis (n=1,754)

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Papers referenced in the video:

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians https://pubmed.ncbi.nlm.nih.gov/31908434/

Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study https://pubmed.ncbi.nlm.nih.gov/28811570/

Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age https://pubmed.ncbi.nlm.nih.gov/29113935/

Age and sex variation in serum albumin concentration: an observational study https://pubmed.ncbi.nlm.nih.gov/26071488/

Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies https://pubmed.ncbi.nlm.nih.gov/33152050/

The gamma gap predicts 4-year all-cause mortality among nonagenarians and centenarians https://pubmed.ncbi.nlm.nih.gov/29348636/

Triglyceride centenarian studies are referenced in this post from my website: https://michaellustgarten.com/2020/02/19/blood-testing-whats-an-optimal-value-for-triglycerides-2/

Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies https://pubmed.ncbi.nlm.nih.gov/24164719/

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults https://pubmed.ncbi.nlm.nih.gov/33313654/

Insulin Sensitivity Is A Hallmark Of Longevity

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HOMA calculator: https://www.omnicalculator.com/health…

Papers referenced in the video:

Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice https://pubmed.ncbi.nlm.nih.gov/24175…

Glucose regulation and oxidative stress in healthy centenarians https://pubmed.ncbi.nlm.nih.gov/12543…

Distribution of blood glucose and prevalence of diabetes among centenarians and oldest-old in China: based on the China Hainan Centenarian Cohort Study and China Hainan Oldest-old Cohort Study https://pubmed.ncbi.nlm.nih.gov/32643…

Prevalence and Ethnic Pattern of Diabetes and Prediabetesin China in 2013 https://pubmed.ncbi.nlm.nih.gov/28655…

Families enriched for exceptional longevity also have increased health-span: findings from the long life family study https://pubmed.ncbi.nlm.nih.gov/24350…

High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?

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Papers referenced in the video:

FGF21 and Chronic Kidney Disease: https://www.sciencedirect.com/science…

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21: https://pubmed.ncbi.nlm.nih.gov/18585…

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877…

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression: https://pubmed.ncbi.nlm.nih.gov/31773…

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses: https://pubmed.ncbi.nlm.nih.gov/28552…

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging: https://pubmed.ncbi.nlm.nih.gov/33131…

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue: https://pubmed.ncbi.nlm.nih.gov/30043…

Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals: https://pubmed.ncbi.nlm.nih.gov/26042…

Lower All-Cause, Cardiovascular, and Cancer Mortality in Centenarians’ Offspring: https://pubmed.ncbi.nlm.nih.gov/15571…

Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study: https://pubmed.ncbi.nlm.nih.gov/20398…