Pneumonia Is A Major Cause of Death In Centenarians: Reducing Risk Via The Gut Microbiome
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Author Archives: Michael Lustgarten
Red Blood Cells Decline During Aging, But Can Be Increased Through Diet
Red blood cells (RBC) are the most abundant cell type in the human body. I’ve tracked my RBC levels in conjunction with diet since 2015, and with the goal of reversing the age-related decline for RBCs, which dietary components have the strongest correlation with RBCs?
https://www.youtube.com/watch?v=3JpyDiNxNeE&feature=youtu.be
Kidney Function Declines During Aging-Can It Be Reversed?
Discussed in the video:
Data for changes in kidney function during aging, kidney function values that are associated with an increased risk of death for all causes
What’s my data for kidney function, 2006 – 2020?
Can diet impact kidney function?
Within my data, which foods are correlated with good kidney function?
How are the individual components of these foods (fiber, protein, omega-3 fatty acids) correlated with kidney function?
Microbes Affect The Hallmarks Of Aging: Mitochondrial Dysfunction (Part II)
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes. Viruses, including SARS-CoV-2 and HSV-1 cause mitochondrial dysfunction-more specifically, they cause mitochondria to release some of their DNA, which triggers antiviral immunity. When considering that blood levels of mitochondrial DNA increase during aging, is aging characterized by an increased viral burden?
Quantifying Biological Age With Aging.ai: 24 Blood Tests Since 2009
The maximal reduction for biological age when using the biological age calculator, Phenotypic Age, is ~20 years. In other words, if I’m 80 years old and my biomarkers are all reflective of youth, the lowest possible biological age will be ~60 years old. One reason for that is the inclusion of chronological age in the prediction of biological age, which adds strength to the correlation while simultaneously limiting the maximal biological age reduction.
To account for the possibility that youthful biomarkers at an older chronological age can yield a biological age that is more than 20 years younger, it’s important to quantify biological age using a tool that doesn’t include chronological age in its calculation. Aging.ai fits that criterion, and in the video I present biological age data with use of aging.ai for 24 blood tests since 2009.
Apigenin Increases Muscle Mass And Improves Muscle Function In Both Young And Old Mice
In an earlier video, I presented data for apigenin’s ability to increase levels of NAD+. In addition to apigenin’s impact on NAD+, apigenin supplementation increases muscle mass, strength, and treadmill running distance in both young and old mice.
Video link for NAD+ is increased in response to apigenin: https://youtu.be/5-2YoGctcCk?list=UUT…
Paper links:
Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7: https://pubmed.ncbi.nlm.nih.gov/29108…
Apigenin Ameliorates the Obesity‐Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice: https://onlinelibrary.wiley.com/doi/a…
Antioxidant Apigenin Relieves Age-Related Muscle Atrophy by Inhibiting Oxidative Stress and Hyperactive Mitophagy and Apoptosis in Skeletal Muscle of Mice: https://pubmed.ncbi.nlm.nih.gov/32857…
The Gut Microbiota Affects Health and Aging (Interview with Modern Healthspan): Parts I-VIII
Here’s the first interview clip (of a series) with Modern Healthspan on YouTube where we discuss the role of the microbiome on health and longevity:
Part II: Skin, Oral Microbiome & Immune System
Part III: Optimal Health with Soluble Fiber
Part IV – Microbial Burden & Hallmarks of Aging
Part V: Spermidine & Immune Support
Part VI: Optimal HDL & LDL
Part VII: Nuts, Seeds & Saturated Fat Intake
Part VII: My Exercise Approach for Longevity
Blood Test #6 In 2020: What’s My Biological Age?
Discussed in the video:
What’s my biological age on blood test #6 in 2020?
What’s my average biological age for 2020, and how does it compare with 2019?
Are there links between calorie intake, cardiovascular fitness (RHR, HRV), and diet composition with my biological age?
Microbial Products Affect the Hallmarks Of Aging: 1) Mitochondrial Function
The Hallmarks of Aging are well established, but what is less discussed is the impact of microbes and/or microbial products. The bacterial metabolite, LPS, increases during aging, and it negatively impacts mitochondrial function, thereby demonstrating a role for microbial products on one of the Hallmarks of Aging, mitochondrial dysfunction.
Redefining Medicine Podcast
Here’s a recent interview where we discussed my journey from an undergraduate student that was interested in aging to scientist!
Michael Lustgarten 