Category Archives: Cholesterol

Is Low LDL Bad For The Epigenetic Pace of Aging?

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Discount Links:
Telomere and Epigenetic Testing: Trudiagnostic.pxf.io/R55XDv
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout

At-Home Metabolomics: https://iollo.com?ref=michael-lustgarten Use Code: CONQUERAGING At Checkout

Oral Microbiome (Enter Code: ConquerAging): https://www.bristlehealth.com/?ref=michaellustgarten

Green Tea: https://www.ochaandco.com/?ref=conqueraging

At-Home Blood Testing: https://getquantify.io/mlustgarten

Diet Tracking: https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

If you’d like to support the channel, you can do that with the website, Buy Me A Coffee: https://www.buymeacoffee.com/mlhnrca

Conquer Aging Or Die Trying Merch! https://my-store-d4e7df.creator-spring.com/
——————————————————————————————————————————-Paper referenced in the video:
Serum Cholesterol and Impact of Age on Coronary Heart Disease Death in More Than 4 Million Veterans https://www.ahajournals.org/doi/10.1161/JAHA.123.030496

ApoB: Is Lower Always Better?

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Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links:
At-Home Blood Testing (including ApoB): https://getquantify.io/mlustgarten

Telomere Length, Epigenetic Testing: Trudiagnostic.pxf.io/R55XDv
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout

Green Tea: https://www.ochaandco.com/?ref=conqueraging

Oral Microbiome (Enter Code: ConquerAging): https://www.bristlehealth.com/?ref=michaellustgarten

Diet Tracking: https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

At-Home Metabolomics: https://iollo.com?ref=michael-lustgarten Use Code: CONQUERAGING At Checkout

If you’d like to support the channel, you can do that with the website, Buy Me A Coffee: https://www.buymeacoffee.com/mlhnrca

Conquer Aging Or Die Trying Merch! https://my-store-d4e7df.creator-spring.com/

——————————————————————————————————————————-Papers referenced in the video:

The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709841/

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
https://pubmed.ncbi.nlm.nih.gov/32203549/

Serum lipid traits and the risk of dementia: A cohort study of 254,575 women and 214,891 men in the UK Biobank
https://pubmed.ncbi.nlm.nih.gov/36247924/

DHEA-S Is A Weakness In My Data: Blood Test #5 in 2022

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Join us on Patreon!
https://www.patreon.com/MichaelLustgartenPhD

Quantify Discount Link (At-Home Blood Testing)
https://getquantify.io/mlustgarten

TruDiagnostic Discount Link (Epigenetic Testing)
CONQUERAGING!
https://bit.ly/3Rken0n

Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

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Support the channel with Buy Me A Coffee!
https://www.buymeacoffee.com/mlhnrca

Papers referenced in the video:
Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults
https://pubmed.ncbi.nlm.nih.gov/30733566/

The Value of Serum Albumin and High-Density Lipoprotein Cholesterol in Defining Mortality Risk in Older Persons with Low Serum Cholesterol
https://pubmed.ncbi.nlm.nih.gov/11559371/

Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives
https://pubmed.ncbi.nlm.nih.gov/31201927/

Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas
https://pubmed.ncbi.nlm.nih.gov/32751564/

Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow up study in a community based cohort (Tanushimaru study)
https://pubmed.ncbi.nlm.nih.gov/18422949/

Centenarian Blood Test Analysis (n=1,754)

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Papers referenced in the video:

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians https://pubmed.ncbi.nlm.nih.gov/31908434/

Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study https://pubmed.ncbi.nlm.nih.gov/28811570/

Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age https://pubmed.ncbi.nlm.nih.gov/29113935/

Age and sex variation in serum albumin concentration: an observational study https://pubmed.ncbi.nlm.nih.gov/26071488/

Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies https://pubmed.ncbi.nlm.nih.gov/33152050/

The gamma gap predicts 4-year all-cause mortality among nonagenarians and centenarians https://pubmed.ncbi.nlm.nih.gov/29348636/

Triglyceride centenarian studies are referenced in this post from my website: https://michaellustgarten.com/2020/02/19/blood-testing-whats-an-optimal-value-for-triglycerides-2/

Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies https://pubmed.ncbi.nlm.nih.gov/24164719/

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults https://pubmed.ncbi.nlm.nih.gov/33313654/

VLDL Increases During Aging, And Is Associated With Adverse Cardiovascular Outcomes

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Papers referenced in the video:

Remnant Cholesterol and Atherosclerotic Cardiovascular Disease Risk: https://www.jacc.org/doi/10.1016/j.ja…

The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling: https://www.sciencedirect.com/science…

Joint distribution of lipoprotein cholesterol classes. The Framingham study: https://pubmed.ncbi.nlm.nih.gov/6573877/

Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS): https://pubmed.ncbi.nlm.nih.gov/20223…

Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease: https://pubmed.ncbi.nlm.nih.gov/33272…

Remnant cholesterol and coronary atherosclerotic plaque burden assessed by computed tomography coronary angiography: https://pubmed.ncbi.nlm.nih.gov/30870…

Premature myocardial infarction is strongly associated with increased levels of remnant cholesterol: https://pubmed.ncbi.nlm.nih.gov/26687…

HDL Update: Age-Related Changes, All-Cause Mortality Risk, And Progress Towards The Optimal Range

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In November 2020, I made a HDL video based on a meta-analysis in ~3.4 million subjects that was published in July 2020. In Dec 2020, a larger study (n=15.8 million subjects) was published-those data are presented in the video, and compared against the meta-analysis.

In addition, I’ve tested my HDL 2 more times since November 2020, so how’s my progress for getting it into the optimal range? Also, I attempt to derive clinical significance by identifying correlations for higher HDL with lower Lp(a) and hs-CRP.

Video link: https://www.youtube.com/watch?v=MUuKlpyvZaU

LDL Cholesterol: What’s Optimal For Health And Longevity?

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LDL is arguably the most debated biomarker in terms of what’s optimal for health. In the video, I present data showing that 100 – 140, not 50 – 70 mg/dL may be optimal in terms of minimizing disease risk and maximizing longevity.

HDL: What’s Optimal For Minimizing Disease Risk And Maximizing Longevity?

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Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 – 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video, I present data for 85y – 115yr olds that additionally suggests HDL in the 55 – 60 mg/dL range as optimal. In addition, I show my own HDL data over the past 15 years (n=34), the correlation for HDL with my diet, and how I plan on consistently increasing my 15-year average HDL of ~44 mg/dL to the 50’s.

Blood Test Analysis: 100 – 111y (Centenarians, Semi- and Super-Centenarians)

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In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and super-centenarians (110y+).