Tag Archives: lifespan

Epigenetic Tests #1 and 2: Horvath, Hannum, DunedinPACE

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TruDiagnostic Discount Link (Epigenetic Testing)
CONQUERAGING!
https://bit.ly/3Rken0n

Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Cronometer Discount Link (Daily diet tracking):
https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

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Papers referenced in the video:
Underlying features of epigenetic aging clocks in vivo and in vitro
https://pubmed.ncbi.nlm.nih.gov/32930491/

DNA methylation‐based measures of biological age: meta‐analysis predicting time to death
https://pubmed.ncbi.nlm.nih.gov/27690265/

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
https://pubmed.ncbi.nlm.nih.gov/26678252/

DunedinPACE, a DNA methylation biomarker of the pace of aging
https://pubmed.ncbi.nlm.nih.gov/35029144/

Effect of Long-Term Caloric Restriction on DNA Methylation Measures of BiologicalAging in Healthy Adults: CALERIE™ Trial Analysis
https://www.medrxiv.org/content/10.1101/2021.09.21.21263912v1.full.pdf

Glycine + N-Acetyl Cysteine Supplementation Increases Lifespan

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Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Cronometer Discount Link (Daily diet tracking):
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Paper referenced in the video:
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/35975308/

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in
Mice Increases Length of Life by Correcting Glutathione
Deficiency, Oxidative Stress, Mitochondrial Dysfunction,
Abnormalities in Mitophagy and Nutrient Sensing,
and Genomic Damage
https://pubmed.ncbi.nlm.nih.gov/35268089/

Glycine and N-acetylcysteine (GlyNAC) supplementation in
older adults improves glutathione deficiency, oxidative
stress, mitochondrial dysfunction, inflammation, insulin
resistance, endothelial dysfunction, genotoxicity, muscle
strength, and cognition: Results of a pilot clinical trial
https://pubmed.ncbi.nlm.nih.gov/33783984/

Lifespan Extension With Calorie Restriction, Fasting, And Circadian Alignment

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Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Cronometer Discount Link (Daily diet tracking):
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Papers referenced in the video:
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice
https://www.nature.com/articles/s42255-021-00466-9

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
https://pubmed.ncbi.nlm.nih.gov/35511946/

Lithocholic Acid: A Gut Bacterial Metabolite That Extends Lifespan

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Papers referenced in the video:
Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors https://www.nature.com/articles/s43587-022-00193-0

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism https://pubmed.ncbi.nlm.nih.gov/30157432/

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production https://pubmed.ncbi.nlm.nih.gov/11371619/

Alterations in xenobiotic metabolism in the long-lived Little mice https://pubmed.ncbi.nlm.nih.gov/17521389/

Bile Acids: A Communication Channel in the Gut-Brain Axis https://pubmed.ncbi.nlm.nih.gov/33085065/

Lithocholic acid significantly improves the survival of Drosophila melanogaster https://pubmed.ncbi.nlm.nih.gov/30051966/

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians https://pubmed.ncbi.nlm.nih.gov/34325466/

Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans https://pubmed.ncbi.nlm.nih.gov/30089729/

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes https://pubmed.ncbi.nlm.nih.gov/20622262/

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians https://pubmed.ncbi.nlm.nih.gov/34325466/

Bile Acids: The Next Frontier In Longevity?

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Papers referenced in the video:

Glycine supplementation extends lifespan of male and female mice https://pubmed.ncbi.nlm.nih.gov/30916479/

Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation https://pubmed.ncbi.nlm.nih.gov/34877949/

17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex https://pubmed.ncbi.nlm.nih.gov/33788371/

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors https://www.nature.com/articles/s43587-022-00193-0

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism https://pubmed.ncbi.nlm.nih.gov/30157432/

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production https://pubmed.ncbi.nlm.nih.gov/11371619/

Alterations in xenobiotic metabolism in the long-lived Little mice https://pubmed.ncbi.nlm.nih.gov/17521389/ Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age https://pubmed.ncbi.nlm.nih.gov/19414512/

Bile Acids: A Communication Channel in the Gut-Brain Axis https://pubmed.ncbi.nlm.nih.gov/33085065/

Blood Test Analysis: Italian Centenarians

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Papers referenced in the video: Laboratory parameters in centenarians of Italian ancestry https://pubmed.ncbi.nlm.nih.gov/17681733/

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians https://pubmed.ncbi.nlm.nih.gov/31908434/

Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study https://pubmed.ncbi.nlm.nih.gov/32623847/

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults https://pubmed.ncbi.nlm.nih.gov/33313654/

Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716867/

11 Centenarian TG studies: https://michaellustgarten.com/2020/02/19/blood-testing-whats-an-optimal-value-for-triglycerides-2/

Association of Hemoglobin Concentration and Its Change With Cardiovascular and All-Cause Mortality https://pubmed.ncbi.nlm.nih.gov/29378732/

U-shaped mortality curve associated with platelet count among older people: a community-based cohort study https://pubmed.ncbi.nlm.nih.gov/26265696/

Blood counts in adult and elderly individuals: defining the norms over eight decades of life https://pubmed.ncbi.nlm.nih.gov/32030733/

Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group https://pubmed.ncbi.nlm.nih.gov/12242321/

Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies https://pubmed.ncbi.nlm.nih.gov/33152050/

Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study https://pubmed.ncbi.nlm.nih.gov/29491346/

Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up https://pubmed.ncbi.nlm.nih.gov/27872510/

White blood cell count and mortality in the Baltimore Longitudinal Study of Aging https://pubmed.ncbi.nlm.nih.gov/17481443/

Age and sex variation in serum albumin concentration: an observational study https://pubmed.ncbi.nlm.nih.gov/26071488/

The gamma gap predicts 4-year all-cause mortality among nonagenarians and centenarians https://pubmed.ncbi.nlm.nih.gov/29348636/

Age-related changes in clinical parameters and their associations with common complex diseases https://pubmed.ncbi.nlm.nih.gov/26623014/

Methionine Restriction Extends Lifespan-What’s Optimal For Protein Intake? n=1 Analysis

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Papers referenced in the video:

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age https://pubmed.ncbi.nlm.nih.gov/19414512/

Low methionine ingestion by rats extends life span https://pubmed.ncbi.nlm.nih.gov/8429371/

Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study https://pubmed.ncbi.nlm.nih.gov/32623847/

Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study https://pubmed.ncbi.nlm.nih.gov/7474221/

Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716867/

Association between low-density lipoprotein cholesterol and cardiovascular mortality in statin non-users: a prospective cohort study in 14.9 million Korean adults https://pubmed.ncbi.nlm.nih.gov/35218344/

Blood counts in adult and elderly individuals: defining the norms over eight decades of life https://pubmed.ncbi.nlm.nih.gov/32030733/