Category Archives: Kidney function

Uremic Metabolites: Kidney Function Biomarkers

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Discount Links:
At-Home Metabolomics: https://iollo.com?ref=michael-lustgarten Use Code: CONQUERAGING At Checkout

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout

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Papers referenced in the video:
Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716867/

Age-related changes in clinical parameters and their associations with common complex diseases
https://pubmed.ncbi.nlm.nih.gov/26623014/

Variation in serum creatinine level is correlated to risk of type 2 diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811691/

Age and cystatin C in healthy adults: a collaborative study
https://pubmed.ncbi.nlm.nih.gov/19749145/

Cystatin C and long-term mortality among subjects with normal creatinine-based estimated glomerular filtration rates: NHANES III (Third National Health and Nutrition Examination Survey)
https://pubmed.ncbi.nlm.nih.gov/21109116/

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors
https://pubmed.ncbi.nlm.nih.gov/37118062/

The Intestinal Microbiota and Metabolites in the Gut-Kidney-Heart Axis of Chronic Kidney Disease
https://pubmed.ncbi.nlm.nih.gov/35370631/

Characteristics of Colon-Derived Uremic Solutes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140561/

Kidney Function: What’s Optimal For Health (And Potentially, Longevity)?

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TruDiagnostic Discount Link (Epigenetic Testing)
CONQUERAGING!
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ConquerAging15
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If you’d like to support the channel, you can do that with the website,
Buy Me A Coffee!
https://www.buymeacoffee.com/mlhnrca

Papers referenced in the video:
A Physiology Clock for Human Aging (preprint)
https://www.biorxiv.org/content/10.1101/2022.04.14.488358v1.full

Age-related changes in clinical parameters and their associations with common complex diseases
https://pubmed.ncbi.nlm.nih.gov/26623014/

Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis
https://pubmed.ncbi.nlm.nih.gov/23360717/

Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716867/

AGE Products Impact Lifespan: Impact Of Hyperglycemia, Kidney Function, And The Microbiome

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Papers referenced in the video:

Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan https://pubmed.ncbi.nlm.nih.gov/18599606/

Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression https://pubmed.ncbi.nlm.nih.gov/17525257/

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N 6-carboxymethyllysine https://pubmed.ncbi.nlm.nih.gov/35241804/

Plasma Carboxymethyl-Lysine, an Advanced Glycation End Product, and All-Cause and Cardiovascular Disease Mortality in Older Community-Dwelling Adults https://pubmed.ncbi.nlm.nih.gov/19682127/

Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community dwelling women https://pubmed.ncbi.nlm.nih.gov/19448391/

Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor KappaB in PBMCs https://pubmed.ncbi.nlm.nih.gov/12606501/

Experimental Hyperglycemia Alters Circulating Concentrations and Renal Clearance of Oxidative and Advanced Glycation End Products in Healthy Obese Humans https://pubmed.ncbi.nlm.nih.gov/30823632/

Novel associations between blood metabolites and kidney function among Bogalusa Heart Study and Multi-Ethnic Study of Atherosclerosis participants https://pubmed.ncbi.nlm.nih.gov/31720858/

Serum Carboxymethyl-lysine, a Dominant Advanced Glycation End Product, is Associated with Chronic Kidney Disease: the Baltimore Longitudinal Study of Aging https://pubmed.ncbi.nlm.nih.gov/19853477/

Centenarian Blood Test Analysis (n=1,754)

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Papers referenced in the video:

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians https://pubmed.ncbi.nlm.nih.gov/31908434/

Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study https://pubmed.ncbi.nlm.nih.gov/28811570/

Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age https://pubmed.ncbi.nlm.nih.gov/29113935/

Age and sex variation in serum albumin concentration: an observational study https://pubmed.ncbi.nlm.nih.gov/26071488/

Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies https://pubmed.ncbi.nlm.nih.gov/33152050/

The gamma gap predicts 4-year all-cause mortality among nonagenarians and centenarians https://pubmed.ncbi.nlm.nih.gov/29348636/

Triglyceride centenarian studies are referenced in this post from my website: https://michaellustgarten.com/2020/02/19/blood-testing-whats-an-optimal-value-for-triglycerides-2/

Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies https://pubmed.ncbi.nlm.nih.gov/24164719/

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults https://pubmed.ncbi.nlm.nih.gov/33313654/

Kidney Function Declines During Aging-Can It Be Reversed?

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Discussed in the video:

Data for changes in kidney function during aging, kidney function values that are associated with an increased risk of death for all causes

What’s my data for kidney function, 2006 – 2020?

Can diet impact kidney function?

Within my data, which foods are correlated with good kidney function?

How are the individual components of these foods (fiber, protein, omega-3 fatty acids) correlated with kidney function?

Quantifying Biological Age: Blood Test #5 in 2020

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My latest blood test results are in-how’s my biological age?

In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them with diet going forward.

Biological Age: Optimal On A Carnivore Diet?

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After going on Joe Rogan’s podcast, Paul Saladino, MD, posted his show notes, which included his blood test results. Based on that data, is his biological age optimal while on a carnivore diet?

Blood Test Analysis: 100 – 111y (Centenarians, Semi- and Super-Centenarians)

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In order to slow aging, it’s important to know how circulating biomarkers change during aging, and how these biomarkers are associated with risk of death for all causes. In this video, I discuss blood test data for the oldest old, including centenarians (100 – 104y), semi-centenarians (105 – 109y), and super-centenarians (110y+).

 

Biological Age Test #4 in 2020: Getting Better or Getting Worse?

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My latest blood test results are in-how’s my biological age? In the video I discuss my dietary approach prior to my latest blood test, the blood test results, and my plan to improve them going forward.

Quantifying Biological Age: Blood Test Measurement #3 in 2020

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In this video, I discuss data for 6 blood test measurements since 2018 that show a Phenotypic (Biological) Age that is ~14 years than my current age (47y).
 
https://youtu.be/85t8vmIgR6s