Tag Archives: Longevity

High FGF21, Low Insulin And Glucose: A Pro-Longevity Strategy?

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Papers referenced in the video:

FGF21 and Chronic Kidney Disease: https://www.sciencedirect.com/science…

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21: https://pubmed.ncbi.nlm.nih.gov/18585…

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877…

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression: https://pubmed.ncbi.nlm.nih.gov/31773…

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice: https://www.ncbi.nlm.nih.gov/pmc/arti…

Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses: https://pubmed.ncbi.nlm.nih.gov/28552…

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging: https://pubmed.ncbi.nlm.nih.gov/33131…

Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue: https://pubmed.ncbi.nlm.nih.gov/30043…

Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals: https://pubmed.ncbi.nlm.nih.gov/26042…

Lower All-Cause, Cardiovascular, and Cancer Mortality in Centenarians’ Offspring: https://pubmed.ncbi.nlm.nih.gov/15571…

Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study: https://pubmed.ncbi.nlm.nih.gov/20398…

Are There Foods That Can Increase NAD? (Part II)

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Papers referenced in the video:

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence: https://pubmed.ncbi.nlm.nih.gov/29514…

NAD and the aging process: Role in life, death and everything in between: https://pubmed.ncbi.nlm.nih.gov/27825…

Flavonoids as inhibitors of human CD38: https://pubmed.ncbi.nlm.nih.gov/21641…

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome: https://pubmed.ncbi.nlm.nih.gov/23172…

Characterization of Anthocyanins and Proanthocyanidins in Some Cultivars of Ribes, Aronia, and Sambucus and Their Antioxidant Capacity: https://pubmed.ncbi.nlm.nih.gov/15612…

Flavonoid glycosides and antioxidant capacity of various blackberry, blueberry and red grape genotypes determined by high-performance liquid chromatography/mass spectrometry: https://onlinelibrary.wiley.com/doi/1…

USDA Database for the Flavonoid Content of Selected Foods: https://www.ars.usda.gov/arsuserfiles… Large changes in NAD levels associated with CD38 expression during HL-60 cell differentiation: https://pubmed.ncbi.nlm.nih.gov/24216…

Effect of genotype and environment on flavonoid concentration and profile of black sorghum grains (incorrectly indicated as Dykes et al. 2013): https://www.sciencedirect.com/science…

Luteolinidin Protects the Post-ischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H): https://jpet.aspetjournals.org/conten…SHOW LESS

Quantifying Biological Age: Blood Test #2 in 2021

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Paper references for Levine’s Phenotypic Age calculator and aging.ai:

An epigenetic biomarker of aging for lifespan and healthspan: https://pubmed.ncbi.nlm.nih.gov/29676…​

Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations:

https://pubmed.ncbi.nlm.nih.gov/29340…

Glutathione Restoration Improves Hallmarks Of Aging in Older Adults

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Papers referenced int the video:

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation: https://pubmed.ncbi.nlm.nih.gov/21795…​

Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial: https://pubmed.ncbi.nlm.nih.gov/33783…​

Glutathione declines during aging (Age-related changes in the glutathione redox system): https://pubmed.ncbi.nlm.nih.gov/11835…

Gut Bacteria Boost Host NAD Metabolism

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Papers referenced in the video:

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway: https://pubmed.ncbi.nlm.nih.gov/32130883/

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism: https://pubmed.ncbi.nlm.nih.gov/27304511/

Aerobic and resistance exercise training reverses age-dependent decline in NAD + salvage capacity in human skeletal muscle: https://pubmed.ncbi.nlm.nih.gov/31207144/

Telomere Length: How Does it Compare Against Other Biological Age Metrics?

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Papers referenced in the video:

The Hallmarks of Aging: https://www.ncbi.nlm.nih.gov/pmc/arti…​

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives: https://www.ncbi.nlm.nih.gov/pmc/arti…​

Telomeres and the natural lifespan limit in humans: https://www.ncbi.nlm.nih.gov/pmc/arti…​

Telomere Length and All-Cause Mortality: A Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/30254…​

Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999-2002: https://pubmed.ncbi.nlm.nih.gov/30999…​

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up: https://elifesciences.org/articles/51507​

Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing? https://pubmed.ncbi.nlm.nih.gov/29149…

Carotenoids Are Associated With A Younger Epigenetic Age And Reduced All-Cause Mortality Risk

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Papers referenced in the video: DNA methylation

GrimAge strongly predicts lifespan and healthspan:

https://pubmed.ncbi.nlm.nih.gov/30669…​

GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality:

https://pubmed.ncbi.nlm.nih.gov/33211…​

Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies: https://pubmed.ncbi.nlm.nih.gov/30475…​

Albumin is included as a biological age predictor:

https://www.ncbi.nlm.nih.gov/pmc/arti…​

https://www.ncbi.nlm.nih.gov/pmc/arti…​

https://www.ncbi.nlm.nih.gov/pmc/arti…​

https://pubmed.ncbi.nlm.nih.gov/30993…​

Age-related change data for albumin:

https://pubmed.ncbi.nlm.nih.gov/26071…​

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages: https://www.nature.com/articles/s4146…

Quantifying Biological Age: Blood Test #1 in 2021

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Results for my first blood test in 2021 are in-what’s my biological age, and how am I optimizing it?

If you’re interested in calculating your biological age, the spreadsheet is included as an Excel file in this link:

https://atomic-temporary-71218033.wpcomstaging.com/2019/09/09/quantifying-biological-age/